KIAA0319 Genotype predicts the number of past concussions in a division i football team: A pilot study

Alexa Walter, Amy A. Herrold, Virginia T. Gallagher, Rosa Lee, Madeleine Scaramuzzo, Tim Bream, Peter Seidenberg, David John Vandenbergh, Kailyn O'Connor, Thomas M. Talavage, Eric A. Nauman, Semyon Slobounov, Hans C. Breiter

Research output: Contribution to journalArticle

Abstract

This candidate gene study evaluated the relationship of a past history of concussion with single nucleotide polymorphisms (SNPs) in nine genes in a small cohort (N = 87) of a nationally ranked Division I football team. Genes and SNPs studied were selected based on their published connection to brain injury and brain development, as well as impulsivity. We used multinomial logistic regression analysis (MLRA) to quantify how well genotype predicted the number of previously diagnosed concussions (three categories: None, one, two or more), while covarying race and number of years participating in football. The rs4504469 SNP for KIAA0319 was the only locus that significantly predicted number of previously diagnosed concussions (p = 0.005, meeting Bonferroni correction for multiple comparisons). The KIAA0319 results raise the hypothesis that having the CT or TT genotype of KIAA0319 may be predictive of a lower incidence of previously diagnosed concussion. This finding raises a number of hypotheses for future pre-clinical research, particularly whether alterations in neural organization related to KIAA0319 rs4504469 lead to reduced susceptibility for lasting head trauma, or greater resilience in the face of repeated subconcussive injury.

Original languageEnglish (US)
Pages (from-to)1115-1124
Number of pages10
JournalJournal of Neurotrauma
Volume36
Issue number7
DOIs
StatePublished - Apr 1 2019

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Football
Single Nucleotide Polymorphism
Genotype
Genes
Impulsive Behavior
Craniocerebral Trauma
Brain Injuries
Logistic Models
Regression Analysis
Incidence
Wounds and Injuries
Brain
Research

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Walter, A., Herrold, A. A., Gallagher, V. T., Lee, R., Scaramuzzo, M., Bream, T., ... Breiter, H. C. (2019). KIAA0319 Genotype predicts the number of past concussions in a division i football team: A pilot study. Journal of Neurotrauma, 36(7), 1115-1124. https://doi.org/10.1089/neu.2017.5622
Walter, Alexa ; Herrold, Amy A. ; Gallagher, Virginia T. ; Lee, Rosa ; Scaramuzzo, Madeleine ; Bream, Tim ; Seidenberg, Peter ; Vandenbergh, David John ; O'Connor, Kailyn ; Talavage, Thomas M. ; Nauman, Eric A. ; Slobounov, Semyon ; Breiter, Hans C. / KIAA0319 Genotype predicts the number of past concussions in a division i football team : A pilot study. In: Journal of Neurotrauma. 2019 ; Vol. 36, No. 7. pp. 1115-1124.
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Walter, A, Herrold, AA, Gallagher, VT, Lee, R, Scaramuzzo, M, Bream, T, Seidenberg, P, Vandenbergh, DJ, O'Connor, K, Talavage, TM, Nauman, EA, Slobounov, S & Breiter, HC 2019, 'KIAA0319 Genotype predicts the number of past concussions in a division i football team: A pilot study', Journal of Neurotrauma, vol. 36, no. 7, pp. 1115-1124. https://doi.org/10.1089/neu.2017.5622

KIAA0319 Genotype predicts the number of past concussions in a division i football team : A pilot study. / Walter, Alexa; Herrold, Amy A.; Gallagher, Virginia T.; Lee, Rosa; Scaramuzzo, Madeleine; Bream, Tim; Seidenberg, Peter; Vandenbergh, David John; O'Connor, Kailyn; Talavage, Thomas M.; Nauman, Eric A.; Slobounov, Semyon; Breiter, Hans C.

In: Journal of Neurotrauma, Vol. 36, No. 7, 01.04.2019, p. 1115-1124.

Research output: Contribution to journalArticle

TY - JOUR

T1 - KIAA0319 Genotype predicts the number of past concussions in a division i football team

T2 - A pilot study

AU - Walter, Alexa

AU - Herrold, Amy A.

AU - Gallagher, Virginia T.

AU - Lee, Rosa

AU - Scaramuzzo, Madeleine

AU - Bream, Tim

AU - Seidenberg, Peter

AU - Vandenbergh, David John

AU - O'Connor, Kailyn

AU - Talavage, Thomas M.

AU - Nauman, Eric A.

AU - Slobounov, Semyon

AU - Breiter, Hans C.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - This candidate gene study evaluated the relationship of a past history of concussion with single nucleotide polymorphisms (SNPs) in nine genes in a small cohort (N = 87) of a nationally ranked Division I football team. Genes and SNPs studied were selected based on their published connection to brain injury and brain development, as well as impulsivity. We used multinomial logistic regression analysis (MLRA) to quantify how well genotype predicted the number of previously diagnosed concussions (three categories: None, one, two or more), while covarying race and number of years participating in football. The rs4504469 SNP for KIAA0319 was the only locus that significantly predicted number of previously diagnosed concussions (p = 0.005, meeting Bonferroni correction for multiple comparisons). The KIAA0319 results raise the hypothesis that having the CT or TT genotype of KIAA0319 may be predictive of a lower incidence of previously diagnosed concussion. This finding raises a number of hypotheses for future pre-clinical research, particularly whether alterations in neural organization related to KIAA0319 rs4504469 lead to reduced susceptibility for lasting head trauma, or greater resilience in the face of repeated subconcussive injury.

AB - This candidate gene study evaluated the relationship of a past history of concussion with single nucleotide polymorphisms (SNPs) in nine genes in a small cohort (N = 87) of a nationally ranked Division I football team. Genes and SNPs studied were selected based on their published connection to brain injury and brain development, as well as impulsivity. We used multinomial logistic regression analysis (MLRA) to quantify how well genotype predicted the number of previously diagnosed concussions (three categories: None, one, two or more), while covarying race and number of years participating in football. The rs4504469 SNP for KIAA0319 was the only locus that significantly predicted number of previously diagnosed concussions (p = 0.005, meeting Bonferroni correction for multiple comparisons). The KIAA0319 results raise the hypothesis that having the CT or TT genotype of KIAA0319 may be predictive of a lower incidence of previously diagnosed concussion. This finding raises a number of hypotheses for future pre-clinical research, particularly whether alterations in neural organization related to KIAA0319 rs4504469 lead to reduced susceptibility for lasting head trauma, or greater resilience in the face of repeated subconcussive injury.

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