Kidney Injury in Liver Disease

Kevin R. Regner, Kai Singbartl

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Acute kidney injury (AKI) occurs frequently in patients with liver disease and increases morbidity and mortality. Hepatorenal syndrome is a common cause of AKI in patients with decompensated cirrhosis and is due to alterations in systemic and renal hemodynamics. Serum creatinine-based estimation of kidney function is a key component of the Model for End-stage Liver Disease score in liver transplant candidates. Continuous renal replacement therapy is used in critically ill patients with liver failure and AKI. Simultaneous liver-kidney transplantation (SLK) may be required in patients with liver failure and prolonged AKI. Identification of appropriate candidates for SLK remains controversial.

Original languageEnglish (US)
Pages (from-to)343-355
Number of pages13
JournalCritical Care Clinics
Volume32
Issue number3
DOIs
StatePublished - Jul 1 2016

Fingerprint

Acute Kidney Injury
Liver Diseases
Kidney
Liver Failure
Wounds and Injuries
Liver Transplantation
Kidney Transplantation
Hepatorenal Syndrome
End Stage Liver Disease
Renal Replacement Therapy
Critical Illness
Creatinine
Fibrosis
Hemodynamics
Morbidity
Transplants
Mortality
Liver
Serum

All Science Journal Classification (ASJC) codes

  • Critical Care and Intensive Care Medicine

Cite this

Regner, Kevin R. ; Singbartl, Kai. / Kidney Injury in Liver Disease. In: Critical Care Clinics. 2016 ; Vol. 32, No. 3. pp. 343-355.
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Regner, KR & Singbartl, K 2016, 'Kidney Injury in Liver Disease', Critical Care Clinics, vol. 32, no. 3, pp. 343-355. https://doi.org/10.1016/j.ccc.2016.03.005

Kidney Injury in Liver Disease. / Regner, Kevin R.; Singbartl, Kai.

In: Critical Care Clinics, Vol. 32, No. 3, 01.07.2016, p. 343-355.

Research output: Contribution to journalReview article

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AU - Singbartl, Kai

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AB - Acute kidney injury (AKI) occurs frequently in patients with liver disease and increases morbidity and mortality. Hepatorenal syndrome is a common cause of AKI in patients with decompensated cirrhosis and is due to alterations in systemic and renal hemodynamics. Serum creatinine-based estimation of kidney function is a key component of the Model for End-stage Liver Disease score in liver transplant candidates. Continuous renal replacement therapy is used in critically ill patients with liver failure and AKI. Simultaneous liver-kidney transplantation (SLK) may be required in patients with liver failure and prolonged AKI. Identification of appropriate candidates for SLK remains controversial.

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