Kidney Injury in Liver Disease

Kevin R. Regner; Kai Singbartl

doi:10.1016/j.ccc.2016.03.005

Kidney Injury in Liver Disease

Kevin R. Regner, Kai Singbartl

Department of Anesthesiology and Perioperative Medicine

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

Acute kidney injury (AKI) occurs frequently in patients with liver disease and increases morbidity and mortality. Hepatorenal syndrome is a common cause of AKI in patients with decompensated cirrhosis and is due to alterations in systemic and renal hemodynamics. Serum creatinine-based estimation of kidney function is a key component of the Model for End-stage Liver Disease score in liver transplant candidates. Continuous renal replacement therapy is used in critically ill patients with liver failure and AKI. Simultaneous liver-kidney transplantation (SLK) may be required in patients with liver failure and prolonged AKI. Identification of appropriate candidates for SLK remains controversial.

Original language	English (US)
Pages (from-to)	343-355
Number of pages	13
Journal	Critical Care Clinics
Volume	32
Issue number	3
DOIs	https://doi.org/10.1016/j.ccc.2016.03.005
State	Published - Jul 1 2016

All Science Journal Classification (ASJC) codes

Critical Care and Intensive Care Medicine

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10.1016/j.ccc.2016.03.005

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title = "Kidney Injury in Liver Disease",

abstract = "Acute kidney injury (AKI) occurs frequently in patients with liver disease and increases morbidity and mortality. Hepatorenal syndrome is a common cause of AKI in patients with decompensated cirrhosis and is due to alterations in systemic and renal hemodynamics. Serum creatinine-based estimation of kidney function is a key component of the Model for End-stage Liver Disease score in liver transplant candidates. Continuous renal replacement therapy is used in critically ill patients with liver failure and AKI. Simultaneous liver-kidney transplantation (SLK) may be required in patients with liver failure and prolonged AKI. Identification of appropriate candidates for SLK remains controversial.",

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AU - Singbartl, Kai

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N2 - Acute kidney injury (AKI) occurs frequently in patients with liver disease and increases morbidity and mortality. Hepatorenal syndrome is a common cause of AKI in patients with decompensated cirrhosis and is due to alterations in systemic and renal hemodynamics. Serum creatinine-based estimation of kidney function is a key component of the Model for End-stage Liver Disease score in liver transplant candidates. Continuous renal replacement therapy is used in critically ill patients with liver failure and AKI. Simultaneous liver-kidney transplantation (SLK) may be required in patients with liver failure and prolonged AKI. Identification of appropriate candidates for SLK remains controversial.

AB - Acute kidney injury (AKI) occurs frequently in patients with liver disease and increases morbidity and mortality. Hepatorenal syndrome is a common cause of AKI in patients with decompensated cirrhosis and is due to alterations in systemic and renal hemodynamics. Serum creatinine-based estimation of kidney function is a key component of the Model for End-stage Liver Disease score in liver transplant candidates. Continuous renal replacement therapy is used in critically ill patients with liver failure and AKI. Simultaneous liver-kidney transplantation (SLK) may be required in patients with liver failure and prolonged AKI. Identification of appropriate candidates for SLK remains controversial.

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JO - Critical Care Clinics

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ER -

Kidney Injury in Liver Disease

Abstract

All Science Journal Classification (ASJC) codes

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