Kidney Injury in Liver Disease

Kevin R. Regner, Kai Singbartl

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Acute kidney injury (AKI) occurs frequently in patients with liver disease and increases morbidity and mortality. Hepatorenal syndrome is a common cause of AKI in patients with decompensated cirrhosis and is due to alterations in systemic and renal hemodynamics. Serum creatinine-based estimation of kidney function is a key component of the Model for End-stage Liver Disease score in liver transplant candidates. Continuous renal replacement therapy is used in critically ill patients with liver failure and AKI. Simultaneous liver-kidney transplantation (SLK) may be required in patients with liver failure and prolonged AKI. Identification of appropriate candidates for SLK remains controversial.

Original languageEnglish (US)
Pages (from-to)343-355
Number of pages13
JournalCritical Care Clinics
Volume32
Issue number3
DOIs
StatePublished - Jul 1 2016

All Science Journal Classification (ASJC) codes

  • Critical Care and Intensive Care Medicine

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