Abstract
Analysis of metastatic prostate cancers has identified the Raf kinase inhibitory protein (RKIP) as a suppressor of metastases. Previous studies demonstrated that RKIP binds to Raf-1 and prevents the activation of the extracellular regulated kinase (ERK) cascade. New work shows that phosphorylation of RKIP by protein kinase C disassociates RKIP from Raf-1 and stimulates its binding to, and inhibition of G-protein-coupled receptor kinase 2 (GRK2). This switching enhances signaling by activation of the ERK pathway and by decreased receptor desensitization.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 91-92 |
| Number of pages | 2 |
| Journal | Trends in Endocrinology and Metabolism |
| Volume | 15 |
| Issue number | 3 |
| DOIs | |
| State | Published - Apr 1 2004 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Endocrinology, Diabetes and Metabolism
- Endocrinology
Cite this
}
Killing two birds with one RKIP. / Goel, Reema; Baldassare, Joseph J.
In: Trends in Endocrinology and Metabolism, Vol. 15, No. 3, 01.04.2004, p. 91-92.Research output: Contribution to journal › Short survey
TY - JOUR
T1 - Killing two birds with one RKIP
AU - Goel, Reema
AU - Baldassare, Joseph J.
PY - 2004/4/1
Y1 - 2004/4/1
N2 - Analysis of metastatic prostate cancers has identified the Raf kinase inhibitory protein (RKIP) as a suppressor of metastases. Previous studies demonstrated that RKIP binds to Raf-1 and prevents the activation of the extracellular regulated kinase (ERK) cascade. New work shows that phosphorylation of RKIP by protein kinase C disassociates RKIP from Raf-1 and stimulates its binding to, and inhibition of G-protein-coupled receptor kinase 2 (GRK2). This switching enhances signaling by activation of the ERK pathway and by decreased receptor desensitization.
AB - Analysis of metastatic prostate cancers has identified the Raf kinase inhibitory protein (RKIP) as a suppressor of metastases. Previous studies demonstrated that RKIP binds to Raf-1 and prevents the activation of the extracellular regulated kinase (ERK) cascade. New work shows that phosphorylation of RKIP by protein kinase C disassociates RKIP from Raf-1 and stimulates its binding to, and inhibition of G-protein-coupled receptor kinase 2 (GRK2). This switching enhances signaling by activation of the ERK pathway and by decreased receptor desensitization.
UR - http://www.scopus.com/inward/record.url?scp=1842418691&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1842418691&partnerID=8YFLogxK
U2 - 10.1016/j.tem.2004.02.004
DO - 10.1016/j.tem.2004.02.004
M3 - Short survey
C2 - 15146872
AN - SCOPUS:1842418691
VL - 15
SP - 91
EP - 92
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
SN - 1043-2760
IS - 3
ER -