Killing two birds with one RKIP

Reema Goel, Joseph J. Baldassare

Research output: Contribution to journalShort survey

9 Citations (Scopus)

Abstract

Analysis of metastatic prostate cancers has identified the Raf kinase inhibitory protein (RKIP) as a suppressor of metastases. Previous studies demonstrated that RKIP binds to Raf-1 and prevents the activation of the extracellular regulated kinase (ERK) cascade. New work shows that phosphorylation of RKIP by protein kinase C disassociates RKIP from Raf-1 and stimulates its binding to, and inhibition of G-protein-coupled receptor kinase 2 (GRK2). This switching enhances signaling by activation of the ERK pathway and by decreased receptor desensitization.

Original languageEnglish (US)
Pages (from-to)91-92
Number of pages2
JournalTrends in Endocrinology and Metabolism
Volume15
Issue number3
DOIs
StatePublished - Apr 1 2004

Fingerprint

raf Kinases
Birds
Proteins
Phosphotransferases
G-Protein-Coupled Receptor Kinase 2
Protein Kinase C
Prostatic Neoplasms
Phosphorylation
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Goel, Reema ; Baldassare, Joseph J. / Killing two birds with one RKIP. In: Trends in Endocrinology and Metabolism. 2004 ; Vol. 15, No. 3. pp. 91-92.
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Killing two birds with one RKIP. / Goel, Reema; Baldassare, Joseph J.

In: Trends in Endocrinology and Metabolism, Vol. 15, No. 3, 01.04.2004, p. 91-92.

Research output: Contribution to journalShort survey

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