Abstract
Analysis of metastatic prostate cancers has identified the Raf kinase inhibitory protein (RKIP) as a suppressor of metastases. Previous studies demonstrated that RKIP binds to Raf-1 and prevents the activation of the extracellular regulated kinase (ERK) cascade. New work shows that phosphorylation of RKIP by protein kinase C disassociates RKIP from Raf-1 and stimulates its binding to, and inhibition of G-protein-coupled receptor kinase 2 (GRK2). This switching enhances signaling by activation of the ERK pathway and by decreased receptor desensitization.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 91-92 |
| Number of pages | 2 |
| Journal | Trends in Endocrinology and Metabolism |
| Volume | 15 |
| Issue number | 3 |
| DOIs | |
| State | Published - Apr 1 2004 |
All Science Journal Classification (ASJC) codes
- Endocrinology, Diabetes and Metabolism
- Endocrinology
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Cite this
Goel, R., & Baldassare, J. J. (2004). Killing two birds with one RKIP. Trends in Endocrinology and Metabolism, 15(3), 91-92. https://doi.org/10.1016/j.tem.2004.02.004