Kinetic analysis shows that vitamin A disposal rate in humans is positively correlated with vitamin A stores

Christopher J. Cifelli, Joanne B. Green, Zhixu Wang, Shian Yin, Robert M. Russell, Guangwen Tang, Michael Henry Green

Research output: Contribution to journalArticle

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Abstract

Vitamin A (VA) kinetics, storage, and disposal rate were determined in well-nourished Chinese and U.S. adults using model-based compartmental analysis. [2H8]Retinyl acetate (8.9 μmol) was orally administered to U.S. (n = 12; 59 ± 9 y; mean ± SD) and Chinese adults (n = 14; 54 ± 4 y) and serum tracer and VA concentrations were measured from 3 h to 56 d. Using the Windows version of the Simulation, Analysis and Modeling software, we determined that the average time from dosing until appearance of labeled retinol in serum was greater in U.S. subjects (40.6 ± 8.47 h) than in Chinese subjects (32.2 ± 5.84 h; P < 0.01). Model-predicted total traced mass (898 ± 637 vs. 237 ± 109 μmol), disposal rate (14.7 ± 5.87 vs. 5.58 ± 2.04 mmol/d), and system residence time (58.9 ± 28.7 vs. 42.9 ± 14.6 d) were greater in U.S. than in Chinese subjects (P < 0.05). The model-predicted VA mass and VA mass estimated by deuterated retinol dilution at 3 and 24 d did not differ. VA disposal rate was positively correlated with VA traced mass in Chinese (R2 = 0.556), U.S. (R2 = 0.579), and all subjects (R 2 = 0.808). Additionally, VA disposal rate was significantly correlated with serum retinol pool size (R2 = 0.227) and retinol concentration (R2 = 0.330) in all subjects. Our results support the hypothesis that VA stores are the principle determinant of VA disposal rate in healthy, well-nourished adults.

Original languageEnglish (US)
Pages (from-to)971-977
Number of pages7
JournalJournal of Nutrition
Volume138
Issue number5
StatePublished - May 1 2008

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Vitamin A
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All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Cifelli, C. J., Green, J. B., Wang, Z., Yin, S., Russell, R. M., Tang, G., & Green, M. H. (2008). Kinetic analysis shows that vitamin A disposal rate in humans is positively correlated with vitamin A stores. Journal of Nutrition, 138(5), 971-977.
Cifelli, Christopher J. ; Green, Joanne B. ; Wang, Zhixu ; Yin, Shian ; Russell, Robert M. ; Tang, Guangwen ; Green, Michael Henry. / Kinetic analysis shows that vitamin A disposal rate in humans is positively correlated with vitamin A stores. In: Journal of Nutrition. 2008 ; Vol. 138, No. 5. pp. 971-977.
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abstract = "Vitamin A (VA) kinetics, storage, and disposal rate were determined in well-nourished Chinese and U.S. adults using model-based compartmental analysis. [2H8]Retinyl acetate (8.9 μmol) was orally administered to U.S. (n = 12; 59 ± 9 y; mean ± SD) and Chinese adults (n = 14; 54 ± 4 y) and serum tracer and VA concentrations were measured from 3 h to 56 d. Using the Windows version of the Simulation, Analysis and Modeling software, we determined that the average time from dosing until appearance of labeled retinol in serum was greater in U.S. subjects (40.6 ± 8.47 h) than in Chinese subjects (32.2 ± 5.84 h; P < 0.01). Model-predicted total traced mass (898 ± 637 vs. 237 ± 109 μmol), disposal rate (14.7 ± 5.87 vs. 5.58 ± 2.04 mmol/d), and system residence time (58.9 ± 28.7 vs. 42.9 ± 14.6 d) were greater in U.S. than in Chinese subjects (P < 0.05). The model-predicted VA mass and VA mass estimated by deuterated retinol dilution at 3 and 24 d did not differ. VA disposal rate was positively correlated with VA traced mass in Chinese (R2 = 0.556), U.S. (R2 = 0.579), and all subjects (R 2 = 0.808). Additionally, VA disposal rate was significantly correlated with serum retinol pool size (R2 = 0.227) and retinol concentration (R2 = 0.330) in all subjects. Our results support the hypothesis that VA stores are the principle determinant of VA disposal rate in healthy, well-nourished adults.",
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Cifelli, CJ, Green, JB, Wang, Z, Yin, S, Russell, RM, Tang, G & Green, MH 2008, 'Kinetic analysis shows that vitamin A disposal rate in humans is positively correlated with vitamin A stores', Journal of Nutrition, vol. 138, no. 5, pp. 971-977.

Kinetic analysis shows that vitamin A disposal rate in humans is positively correlated with vitamin A stores. / Cifelli, Christopher J.; Green, Joanne B.; Wang, Zhixu; Yin, Shian; Russell, Robert M.; Tang, Guangwen; Green, Michael Henry.

In: Journal of Nutrition, Vol. 138, No. 5, 01.05.2008, p. 971-977.

Research output: Contribution to journalArticle

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AU - Russell, Robert M.

AU - Tang, Guangwen

AU - Green, Michael Henry

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Cifelli CJ, Green JB, Wang Z, Yin S, Russell RM, Tang G et al. Kinetic analysis shows that vitamin A disposal rate in humans is positively correlated with vitamin A stores. Journal of Nutrition. 2008 May 1;138(5):971-977.