Background: The acetyl-CoA biosynthetic pathways of the malaria parasite are unclear. Results: 13C-Labeling experiments in parasites lacking a functional pyruvate dehydrogenase (PDH) complex show that thePDH does not contribute significantly to the acetyl-CoA pool. Conclusion: The majority of acetyl-CoA biosynthesis in the parasite derives from a PDH-like enzyme and acetyl-CoA synthetase. Significance: The two routes for acetyl-CoA synthesis appear to have separate functions.
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology