Kinetic parameters for plasma beta-endorphin in lean and obese Zucker rats

D. Rodd, P. A. Farrell, A. L. Caston, M. H. Green

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

To determine plasma clearance kinetics for beta-endorphin (BE) by empirical compartmental analysis, a bolus of radioactive labeled 125I-BE was rapidly injected into a carotid artery catheter of unanesthetized lean (L) and obese (O) Zucker rats. The plasma disappearance of 125I was followed over a 3-h period. A 3-component exponential equation provided the best fit for plasma data. Plasma transit times were very short (10 s); however, plasma fractional catabolic rate was much slower. Plasma mean residence time was similar for both groups (50 min) as was recycle time (1.3 min). These data suggest that BE plasma disappearance kinetics are similar in L and O rats.

Original languageEnglish (US)
Pages (from-to)345-349
Number of pages5
JournalPeptides
Volume12
Issue number2
DOIs
StatePublished - Jan 1 1991

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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