TY - JOUR
T1 - Kinetics of 1,3-dipolar cycloaddition on the surfaces of Au nanoparticles
AU - Thode, Christopher Jay
AU - Williams, Mary Elizabeth
N1 - Funding Information:
We gratefully acknowledge support of this work by grants from the National Science Foundation (CHE0239-702) and a 3M Untenured Faculty Award.
PY - 2008/4/1
Y1 - 2008/4/1
N2 - Triazole formation via 1,3-dipolar cycloaddition, or "click" chemistry, is a powerful synthetic method for incorporating chemical functionality onto the surfaces of Au nanoparticles. To investigate the factors that govern azide/alkyne reactivity at particle surfaces, we measured the general kinetic trends for the uncatalyzed reaction using FTIR spectroscopy. This study examines the roles of ligand length, electronic substitution of the alkyne species, and solvent on the reaction under pseudo-first-order conditions. The conversion of azide to triazole is found to depend more strongly on the relative surface coverage of azide terminated alkanethiol than on the ligand length and solvent.
AB - Triazole formation via 1,3-dipolar cycloaddition, or "click" chemistry, is a powerful synthetic method for incorporating chemical functionality onto the surfaces of Au nanoparticles. To investigate the factors that govern azide/alkyne reactivity at particle surfaces, we measured the general kinetic trends for the uncatalyzed reaction using FTIR spectroscopy. This study examines the roles of ligand length, electronic substitution of the alkyne species, and solvent on the reaction under pseudo-first-order conditions. The conversion of azide to triazole is found to depend more strongly on the relative surface coverage of azide terminated alkanethiol than on the ligand length and solvent.
UR - http://www.scopus.com/inward/record.url?scp=39549122222&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=39549122222&partnerID=8YFLogxK
U2 - 10.1016/j.jcis.2007.12.027
DO - 10.1016/j.jcis.2007.12.027
M3 - Article
C2 - 18191872
AN - SCOPUS:39549122222
VL - 320
SP - 346
EP - 352
JO - Journal of Colloid and Interface Science
JF - Journal of Colloid and Interface Science
SN - 0021-9797
IS - 1
ER -