Kinetics of synaptic current

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Current kinetics takes into account three key components of receptor function. They include an open or activated state, a deactivated state, and a desensitized state (Fig. 1) As the ligand binds to the receptor, a conformational change takes place allowing pore formation and ion permeability, defining an activated state. The deactivated state refers to a receptor transitioning from a bound to an unbound agonist state with decreasing ionic permeability as the channel closes. This process occurs as the agonist concentration becomes zero. Finally, a desensitized state refers to a reduced response to an agonist often due to prolonged agonist exposure (i.e., the receptor is in a non-conducting state despite agonist being bound to the receptor). Desensitization can be altered by neurotransmitter clearance from the synaptic cleft via diffusion, degradation, or reuptake through transporters expressed on neuronal or glial cells. Prolonged exposure to neurotransmission may induce desensitization of receptors, while rapid removal of the neurotransmitter from the synaptic cleft may reduce desensitization.

Original languageEnglish (US)
Title of host publicationNeuromethods
PublisherHumana Press Inc.
Pages193-205
Number of pages13
DOIs
StatePublished - Oct 1 2016

Publication series

NameNeuromethods
Volume112
ISSN (Print)0893-2336
ISSN (Electronic)1940-6045

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Psychiatry and Mental health

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  • Cite this

    Graziane, N., & Dong, Y. (2016). Kinetics of synaptic current. In Neuromethods (pp. 193-205). (Neuromethods; Vol. 112). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-3274-0_17