Kyotorphin and d-kyotorphin stimulate Met-enkephalin release from rat striatum in vitro

P. K. Janicki, A. W. Lipkowski

Research output: Contribution to journalArticle

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Abstract

The release of immunoreactive Met-enkephalin (I-ME) from the rat striatum was studied in vitro using a batch technique. A basal release of the order of 2-3% of total I-ME tissue content per 10 min was found. Both dipeptides kyotorphin and d-kyotorphin produced equipotently dose-dependent I-ME release, with 0.5 mM maximal concentration causing 2-3-fold stimulation oe release. This release was calcium-dependent. In concentrations up to 1 mM both dipeptides did not change the basal release of [3H]noradrenaline, [3H]GABA, [3H]d-aspartate and immunoreactive beta-endorphin from varioys brain structures. The results support a role of kyotorphin as a specific I-ME-releasing factor in the rat brain.

Original languageEnglish (US)
Pages (from-to)73-77
Number of pages5
JournalNeuroscience letters
Volume43
Issue number1
DOIs
StatePublished - Dec 23 1983

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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