Lab-on-a-chip technologies for single-molecule studies

Yanhui Zhao, Danqi Chen, Hongjun Yue, Jarrod B. French, Joseph Rufo, Stephen Benkovic, Tony Jun Huang

Research output: Contribution to journalReview article

33 Citations (Scopus)

Abstract

Recent developments on various lab-on-a-chip techniques allow miniaturized and integrated devices to perform on-chip single-molecule studies. Fluidic-based platforms that utilize unique microscale fluidic behavior are capable of conducting single-molecule experiments with high sensitivities and throughputs, while biomolecular systems can be studied on-chip using techniques such as DNA curtains, magnetic tweezers, and solid-state nanopores. The advances of these on-chip single-molecule techniques lead to next-generation lab-on-a-chip devices, such as DNA transistors, and single-molecule real-time (SMRT) technology for rapid and low-cost whole genome DNA sequencing. In this Focus article, we will discuss some recent successes in the development of lab-on-a-chip techniques for single-molecule studies and expound our thoughts on the near future of on-chip single-molecule studies.

Original languageEnglish (US)
Pages (from-to)2183-2198
Number of pages16
JournalLab on a Chip
Volume13
Issue number12
DOIs
StatePublished - Jun 21 2013

Fingerprint

Lab-on-a-chip
Nanopores
Technology
Equipment and Supplies
Molecules
DNA
DNA Sequence Analysis
Fluidics
Genome
Costs and Cost Analysis
Transistors
Genes
Throughput
Costs

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

Cite this

Zhao, Y., Chen, D., Yue, H., French, J. B., Rufo, J., Benkovic, S., & Huang, T. J. (2013). Lab-on-a-chip technologies for single-molecule studies. Lab on a Chip, 13(12), 2183-2198. https://doi.org/10.1039/c3lc90042h
Zhao, Yanhui ; Chen, Danqi ; Yue, Hongjun ; French, Jarrod B. ; Rufo, Joseph ; Benkovic, Stephen ; Huang, Tony Jun. / Lab-on-a-chip technologies for single-molecule studies. In: Lab on a Chip. 2013 ; Vol. 13, No. 12. pp. 2183-2198.
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Zhao, Y, Chen, D, Yue, H, French, JB, Rufo, J, Benkovic, S & Huang, TJ 2013, 'Lab-on-a-chip technologies for single-molecule studies', Lab on a Chip, vol. 13, no. 12, pp. 2183-2198. https://doi.org/10.1039/c3lc90042h

Lab-on-a-chip technologies for single-molecule studies. / Zhao, Yanhui; Chen, Danqi; Yue, Hongjun; French, Jarrod B.; Rufo, Joseph; Benkovic, Stephen; Huang, Tony Jun.

In: Lab on a Chip, Vol. 13, No. 12, 21.06.2013, p. 2183-2198.

Research output: Contribution to journalReview article

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Zhao Y, Chen D, Yue H, French JB, Rufo J, Benkovic S et al. Lab-on-a-chip technologies for single-molecule studies. Lab on a Chip. 2013 Jun 21;13(12):2183-2198. https://doi.org/10.1039/c3lc90042h