Lab-on-a-chip technologies for single-molecule studies

Yanhui Zhao, Danqi Chen, Hongjun Yue, Jarrod B. French, Joseph Rufo, Stephen J. Benkovic, Tony Jun Huang

Research output: Contribution to journalReview article

35 Scopus citations


Recent developments on various lab-on-a-chip techniques allow miniaturized and integrated devices to perform on-chip single-molecule studies. Fluidic-based platforms that utilize unique microscale fluidic behavior are capable of conducting single-molecule experiments with high sensitivities and throughputs, while biomolecular systems can be studied on-chip using techniques such as DNA curtains, magnetic tweezers, and solid-state nanopores. The advances of these on-chip single-molecule techniques lead to next-generation lab-on-a-chip devices, such as DNA transistors, and single-molecule real-time (SMRT) technology for rapid and low-cost whole genome DNA sequencing. In this Focus article, we will discuss some recent successes in the development of lab-on-a-chip techniques for single-molecule studies and expound our thoughts on the near future of on-chip single-molecule studies.

Original languageEnglish (US)
Pages (from-to)2183-2198
Number of pages16
JournalLab on a Chip
Issue number12
StatePublished - Jun 21 2013

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

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  • Cite this

    Zhao, Y., Chen, D., Yue, H., French, J. B., Rufo, J., Benkovic, S. J., & Huang, T. J. (2013). Lab-on-a-chip technologies for single-molecule studies. Lab on a Chip, 13(12), 2183-2198.