Abstract
Sequestration of Plasmodium falciparum parasites within the placenta often leads to an accumulation of macrophages within the intervillous space and increased production of tumor necrosis factor alpha (TNF-α), a cytokine associated with placental pathology and poor pregnancy outcomes. P. falciparum glycosylphosphatidylinositol (GPI) anchors have been shown to be the major parasite component that induces TNF-7alpha; production by monocytes and macrophages. Antibodies against P. falciparum GPI (anti-PfGPI), however, can inhibit the induction of TNF-α and inflammation. Thus, the study was undertaken to determine whether anti-PfGPI antibodies down-regulate inflammatory-type changes in the placentas of women with malaria. Anti-PfGPI immunoglobtitin M (IgM) and IgG levels were measured in 380 pregnant women with or without placental malaria, including those who delivered prematurely and at term. Results showed that anti-PfGPI antibody levels increased with gravidity and age and that malaria infection boosted anti-PfGPI antibodies in pregnant women. However, no association was found between anti-PfGPI antibodies and placental TNF-α levels or the presence of acute or chronic placental malaria. Furthermore, anti-PfGPI antibody levels were similar in women with preterm and full-term deliveries and were not associated with an increase in infant birth weight. Thus, these results fail to support a strong role for anti-PfGPI antibodies in the prevention of chronic placental malaria infections and malaria-associated poor birth outcomes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5267-5273 |
| Number of pages | 7 |
| Journal | Infection and Immunity |
| Volume | 72 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 1 2004 |
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All Science Journal Classification (ASJC) codes
- Parasitology
- Microbiology
- Immunology
- Infectious Diseases
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Lack of an association between antibodies to Plasmodium falciparum glycosylpliosphatidylinositols and malaria-associated placental changes in Cameroonian women with preterm and full-term deliveries. / Suguitan, Amorsolo L.; Gowda, Channe; Fouda, Genevieve; Thuita, Lucy; Zhou, Ainong; Djokam, Rosine; Metenou, Simon; Leke, Rose G.F.; Taylor, Diane Wallace.
In: Infection and Immunity, Vol. 72, No. 9, 01.09.2004, p. 5267-5273.Research output: Contribution to journal › Article
TY - JOUR
T1 - Lack of an association between antibodies to Plasmodium falciparum glycosylpliosphatidylinositols and malaria-associated placental changes in Cameroonian women with preterm and full-term deliveries
AU - Suguitan, Amorsolo L.
AU - Gowda, Channe
AU - Fouda, Genevieve
AU - Thuita, Lucy
AU - Zhou, Ainong
AU - Djokam, Rosine
AU - Metenou, Simon
AU - Leke, Rose G.F.
AU - Taylor, Diane Wallace
PY - 2004/9/1
Y1 - 2004/9/1
N2 - Sequestration of Plasmodium falciparum parasites within the placenta often leads to an accumulation of macrophages within the intervillous space and increased production of tumor necrosis factor alpha (TNF-α), a cytokine associated with placental pathology and poor pregnancy outcomes. P. falciparum glycosylphosphatidylinositol (GPI) anchors have been shown to be the major parasite component that induces TNF-7alpha; production by monocytes and macrophages. Antibodies against P. falciparum GPI (anti-PfGPI), however, can inhibit the induction of TNF-α and inflammation. Thus, the study was undertaken to determine whether anti-PfGPI antibodies down-regulate inflammatory-type changes in the placentas of women with malaria. Anti-PfGPI immunoglobtitin M (IgM) and IgG levels were measured in 380 pregnant women with or without placental malaria, including those who delivered prematurely and at term. Results showed that anti-PfGPI antibody levels increased with gravidity and age and that malaria infection boosted anti-PfGPI antibodies in pregnant women. However, no association was found between anti-PfGPI antibodies and placental TNF-α levels or the presence of acute or chronic placental malaria. Furthermore, anti-PfGPI antibody levels were similar in women with preterm and full-term deliveries and were not associated with an increase in infant birth weight. Thus, these results fail to support a strong role for anti-PfGPI antibodies in the prevention of chronic placental malaria infections and malaria-associated poor birth outcomes.
AB - Sequestration of Plasmodium falciparum parasites within the placenta often leads to an accumulation of macrophages within the intervillous space and increased production of tumor necrosis factor alpha (TNF-α), a cytokine associated with placental pathology and poor pregnancy outcomes. P. falciparum glycosylphosphatidylinositol (GPI) anchors have been shown to be the major parasite component that induces TNF-7alpha; production by monocytes and macrophages. Antibodies against P. falciparum GPI (anti-PfGPI), however, can inhibit the induction of TNF-α and inflammation. Thus, the study was undertaken to determine whether anti-PfGPI antibodies down-regulate inflammatory-type changes in the placentas of women with malaria. Anti-PfGPI immunoglobtitin M (IgM) and IgG levels were measured in 380 pregnant women with or without placental malaria, including those who delivered prematurely and at term. Results showed that anti-PfGPI antibody levels increased with gravidity and age and that malaria infection boosted anti-PfGPI antibodies in pregnant women. However, no association was found between anti-PfGPI antibodies and placental TNF-α levels or the presence of acute or chronic placental malaria. Furthermore, anti-PfGPI antibody levels were similar in women with preterm and full-term deliveries and were not associated with an increase in infant birth weight. Thus, these results fail to support a strong role for anti-PfGPI antibodies in the prevention of chronic placental malaria infections and malaria-associated poor birth outcomes.
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U2 - 10.1128/IAI.72.9.5267-5273.2004
DO - 10.1128/IAI.72.9.5267-5273.2004
M3 - Article
C2 - 15322022
AN - SCOPUS:4544281157
VL - 72
SP - 5267
EP - 5273
JO - Infection and Immunity
JF - Infection and Immunity
SN - 0019-9567
IS - 9
ER -