Lack of association between ORAI1/CRACM1 Gene Polymorphisms and Kawasaki disease in the Taiwanese children

Ho Chang Kuo, Ying Jui Lin, Suh Hang Hank Juo, Yu Wen Hsu, Wei Chiao Chen, Kuender D. Yang, Chi Di Liang, Shengyu Yang, Mei Chyn Chao, Hong Ren Yu, Shouyan Wang, Li Yan Lin, Wei Chiao Chang

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15 Scopus citations

Abstract

Objective Kawasaki disease (KD) is characterized by systemic vasculitis of an unknown cause. A previous study has indicated that a polymorphism of the inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) gene is involved in the susceptibility to KD. ORAI (also known as CRACM1) is one of the components of store-operated calcium channels involved in regulating immune and inflammatory reactions. This study was conducted to investigate if polymorphisms in ORAI1/ CRACM1, a gene downstream from ITPKC, are associated with KD susceptibility and clinical outcomes. Materials and Methods A total of 1,056 subjects (341 KD patients and 715 controls) were investigated to identify five tagging single nucleotide polymorphisms (tSNPs) in ORAI1/ CRACM1 (rs12313273, rs6486795, rs7135617, rs12320939, and rs712853) by using the TaqMan Allelic Discrimination assay. Results No significant associations between genotype and allele frequency of the five ORAI1/CRACM1 tSNPs were observed in the KD patients and controls. In KD patients, no significant associations between ORAI1/CRACM1 polymorphisms and coronary artery lesion (CAL) formation or intravenous immunoglobulin (IVIG) treatment response were observed. The results from haplotype analysis were insignificant. Conclusions This study showed for the first time that ORAI1/CRACM1 polymorphisms are not associated with KD susceptibility, CAL formation, or IVIG treatment response in the Taiwanese population.

Original languageEnglish (US)
Pages (from-to)650-655
Number of pages6
JournalJournal of Clinical Immunology
Volume31
Issue number4
DOIs
StatePublished - Aug 1 2011

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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