Lack of association of hepatitis C virus load and genotype with risk of end-stage liver disease in patients with human immunodeficiency virus coinfection

J. J. Goedert, A. Hatzakis, K. E. Sherman, M. E. Eyster

    Research output: Contribution to journalArticlepeer-review

    38 Scopus citations

    Abstract

    In hepatitis C virus (HCV) infection, virus load and the risk for HCV-related end-stage liver disease (ESLD) are increased among persons with human immunodeficiency virus (HIV) coinfection. To clarify these relationships, 42 hemophilic patients who developed ESLD and random samples from 164 hemophilic patients with HCV infection alone and 146 with HCV-HIV coinfection were tested for HCV load and genotype. HCV genotype was unrelated to HIV and age. In contrast, HCV load was higher with older age (Ptrend=.0001) and with HIV coinfection (6.2 vs. 5.9 log10 genome equivalents/mL, P=.0001). During 16 years of follow-up of dually infected patients, ESLD risk was unrelated to HCV load overall (Ptrend=.64) or separately to HCV genotype 1 and genotypes 2 or 3 (Ptrend.70). Irrespective of virus load, incidence of ESLD was marginally increased 2-fold (95% confidence interval, 0.8-5.6) with HCV genotype 1. Understanding the discordance between HCV load and ESLD, despite HIVs link to each of these, may help clarify the pathogenesis of HCV-related disease.

    Original languageEnglish (US)
    Pages (from-to)1202-1205
    Number of pages4
    JournalJournal of Infectious Diseases
    Volume184
    Issue number9
    DOIs
    StatePublished - Nov 1 2001

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Infectious Diseases

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