Lack of effect of flurothyl, a non-anesthetic fluorinated ether, on rat brain synaptic plasma membrane calcium-ATPase

J. L. Horn, Piotr Janicki, J. J. Franks

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Plasma membrane Ca2+-ATPase (PMCA), a regulator of intracellular calcium, is inhibited by volatile anesthetics and by xenon and nitrous oxide. Response of a cellular system to anesthetics, particularly to volatile agents, raises the question of non-specific, even toxic, side effects unrelated to anesthetic action. Compounds with chemical and physical properties similar to halogenated anesthetics, but which lack anesthetic effect, have been used to address this question. We have compared the effects of halothane and flurothyl, a non-anesthetic fluorinated ether, on PMCA Ca2+ transport across isolated brain synaptic plasma membranes (SPM). Flurothyl, at concentrations predicted by the Meyer-Overton curve to range from 0.4 to 2.6 MAC (minimum alveolar concentration), had no significant on PMCA activity. In contrast halothane, 1.3 MAC, reduced Ca2+ transport 30 to 40 %. These findings provide further evidence for a specific effect of inhalation anesthetics on neuronal plasma membrane Ca2-+ATPase.

Original languageEnglish (US)
Pages (from-to)179-183
Number of pages5
JournalLife Sciences
Volume64
Issue number14
DOIs
StatePublished - Feb 26 1999

Fingerprint

Plasma Membrane Calcium-Transporting ATPases
Flurothyl
Synaptic Membranes
Cell membranes
Ether
Calcium-Transporting ATPases
Anesthetics
Rats
Brain
Cell Membrane
Halothane
Inhalation Anesthetics
Xenon
Poisons
Nitrous Oxide
Chemical properties
Physical properties
Calcium

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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abstract = "Plasma membrane Ca2+-ATPase (PMCA), a regulator of intracellular calcium, is inhibited by volatile anesthetics and by xenon and nitrous oxide. Response of a cellular system to anesthetics, particularly to volatile agents, raises the question of non-specific, even toxic, side effects unrelated to anesthetic action. Compounds with chemical and physical properties similar to halogenated anesthetics, but which lack anesthetic effect, have been used to address this question. We have compared the effects of halothane and flurothyl, a non-anesthetic fluorinated ether, on PMCA Ca2+ transport across isolated brain synaptic plasma membranes (SPM). Flurothyl, at concentrations predicted by the Meyer-Overton curve to range from 0.4 to 2.6 MAC (minimum alveolar concentration), had no significant on PMCA activity. In contrast halothane, 1.3 MAC, reduced Ca2+ transport 30 to 40 {\%}. These findings provide further evidence for a specific effect of inhalation anesthetics on neuronal plasma membrane Ca2-+ATPase.",
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Lack of effect of flurothyl, a non-anesthetic fluorinated ether, on rat brain synaptic plasma membrane calcium-ATPase. / Horn, J. L.; Janicki, Piotr; Franks, J. J.

In: Life Sciences, Vol. 64, No. 14, 26.02.1999, p. 179-183.

Research output: Contribution to journalArticle

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