Lack of evidence for perfluorodecanoyl‐ or perfluorooctanoyl‐coenzyme a formation in male and female rats

Benedict I. Kuslikis, John Patrick Vanden Heuvel, Richard E. Peterson

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Perfluorodecanoic (PFDA) and perfluorooctanoic (PFOA) acids belong to the structurally diverse group of compounds known to cause peroxisomal proliferation. It has been hypothesized that the common mode of action of these compounds is that they act through an activated coenzyme A (CoA) thioester. Using rat liver microsomal and isolated rat hepatocyte incubation conditions that were effective in producing a COA conjugate of clofibric acid, no corresponding COA derivative could be found for either PFDA or PFOA.

Original languageEnglish (US)
Pages (from-to)25-29
Number of pages5
JournalJournal of Biochemical Toxicology
Volume7
Issue number1
DOIs
StatePublished - Jan 1 1992

Fingerprint

perfluorooctanoic acid
Rats
Clofibric Acid
Coenzyme A
Liver
Hepatocytes
Derivatives
perfluorodecanoic acid

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

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abstract = "Perfluorodecanoic (PFDA) and perfluorooctanoic (PFOA) acids belong to the structurally diverse group of compounds known to cause peroxisomal proliferation. It has been hypothesized that the common mode of action of these compounds is that they act through an activated coenzyme A (CoA) thioester. Using rat liver microsomal and isolated rat hepatocyte incubation conditions that were effective in producing a COA conjugate of clofibric acid, no corresponding COA derivative could be found for either PFDA or PFOA.",
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Lack of evidence for perfluorodecanoyl‐ or perfluorooctanoyl‐coenzyme a formation in male and female rats. / Kuslikis, Benedict I.; Vanden Heuvel, John Patrick; Peterson, Richard E.

In: Journal of Biochemical Toxicology, Vol. 7, No. 1, 01.01.1992, p. 25-29.

Research output: Contribution to journalArticle

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