Lack of evidence for perfluorodecanoyl‐ or perfluorooctanoyl‐coenzyme a formation in male and female rats

Benedict I. Kuslikis, John P. Vanden Heuvel, Richard E. Peterson

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Perfluorodecanoic (PFDA) and perfluorooctanoic (PFOA) acids belong to the structurally diverse group of compounds known to cause peroxisomal proliferation. It has been hypothesized that the common mode of action of these compounds is that they act through an activated coenzyme A (CoA) thioester. Using rat liver microsomal and isolated rat hepatocyte incubation conditions that were effective in producing a COA conjugate of clofibric acid, no corresponding COA derivative could be found for either PFDA or PFOA.

Original languageEnglish (US)
Pages (from-to)25-29
Number of pages5
JournalJournal of Biochemical Toxicology
Volume7
Issue number1
DOIs
StatePublished - 1992

All Science Journal Classification (ASJC) codes

  • Toxicology

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