Lack of habituation of pain evoked potentials after naloxone

Piotr Janicki, J. Libich, W. Gumulka

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9 Scopus citations

Abstract

Pain evoked potentials (EPs) were recorded in nucleus caudatus (NC) of rabbits after electrical stimulation of the dental pulp. After 50-60 noxious stimuli the decrease in amplitude of evoked potentials occurred. Naloxone, 1 mg/kg, temporarily abolished this effect and even after 350 noxious stimuli the habituation was not observed. On the other hand, naloxone did not affect the diminution of monosynaptic transcallosal potentials (TC-EP) evoked by repeated stimulation. It may be suggested that the habituation of EPs elicited by pain stimulation is due to endorphin release.

Original languageEnglish (US)
Pages (from-to)201-205
Number of pages5
JournalPolish Journal of Pharmacology and Pharmacy
Volume31
Issue number3
StatePublished - 1979

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science
  • Pharmacology

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