Lack of Ir-gene control in T-cell responses restricted by allogeneic MHC molecules

Z. A. Nagy, N. Ishii, C. N. Baxevanis, J. Klein

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Abstract

T cells were depleted of alloreactive cells by 5-bromo-2-deoxyuridine (BUdR) and light treatment, and were subsequently primed in vitro using allogeneic antigen presenting cells (APC) and antigens, the response to which is under immune response (Ir)-gene control. Antigen-specific secondary proliferative responses restricted by allogeneic Ia molecules of the APC were obtained in all strain combinations tested, irrespective of the Ir phenotype of either the T cell or the APC. Thus the data establish that the response of T cells to antigen presented by allogeneic APC is not under Ir-gene control. The implications of this finding to the mechanism of Ir-gene controlled non-responsiveness, and its impact on current views of the T-cell repertoire are discussed.

Original languageEnglish (US)
Pages (from-to)74-78
Number of pages5
JournalBehring Institute Mitteilungen
VolumeNo. 70
Publication statusPublished - Jan 1 1982

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All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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Nagy, Z. A., Ishii, N., Baxevanis, C. N., & Klein, J. (1982). Lack of Ir-gene control in T-cell responses restricted by allogeneic MHC molecules. Behring Institute Mitteilungen, No. 70, 74-78.