Lactulose-induced pneumatosis intestinalis and pneumoperitoneum

Robert A. Goodman, Thomas Riley III

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

A case of PI in a 57-year-old patient with colonic inertia treated with lactulose for PSE secondary to cirrhosis is described. The colonic inertia led to longer transit time. Retained lactulose and a build-up of carbon dioxide and hydrogen gas occurred in the setting of altered bacterial flora deficient in hydrogen metabolism. The increased gas pressure caused extravasation of air into the intestine, causing PI with pneumoperitoneum. They both resolved with discontinuation of lactulose.

Original languageEnglish (US)
Pages (from-to)2549-2553
Number of pages5
JournalDigestive Diseases and Sciences
Volume46
Issue number11
DOIs
StatePublished - Nov 20 2001

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Lactulose
Pneumoperitoneum
Constipation
Hydrogen
Gases
Carbon Dioxide
Intestines
Fibrosis
Air
Pressure

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

Cite this

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Lactulose-induced pneumatosis intestinalis and pneumoperitoneum. / Goodman, Robert A.; Riley III, Thomas.

In: Digestive Diseases and Sciences, Vol. 46, No. 11, 20.11.2001, p. 2549-2553.

Research output: Contribution to journalArticle

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