Large scale comparison of innate responses to viral and bacterial pathogens in mouse and macaque

Guy Zinman, Rachel Brower-Sinning, Chineye H. Emeche, Jason Ernst, Grace Tzu Wei Huang, Shaun Mahony, Amy J. Myers, Dawn M. O'Dee, Jo Anne L. Flynn, Gerard J. Nau, Ted M. Ross, Russell D. Salter, Panayiotis V. Benos, Ziv Bar Joseph, Penelope A. Morel

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Viral and bacterial infections of the lower respiratory tract are major causes of morbidity and mortality worldwide. Alveolar macrophages line the alveolar spaces and are the first cells of the immune system to respond to invading pathogens. To determine the similarities and differences between the responses of mice and macaques to invading pathogens we profiled alveolar macrophages from these species following infection with two viral (PR8 and Fuj/02 influenza A) and two bacterial (Mycobacterium tuberculosis and Francisella tularensis Schu S4) pathogens. Cells were collected at 6 time points following each infection and expression profiles were compared across and between species. Our analyses identified a core set of genes, activated in both species and across all pathogens that were predominantly part of the interferon response pathway. In addition, we identified similarities across species in the way innate immune cells respond to lethal versus non-lethal pathogens. On the other hand we also found several species and pathogen specific response patterns. These results provide new insights into mechanisms by which the innate immune system responds to, and interacts with, invading pathogens.

Original languageEnglish (US)
Article numbere22401
JournalPloS one
Volume6
Issue number7
DOIs
StatePublished - Jul 26 2011

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Macaca
Pathogens
Alveolar Macrophages
pathogens
Immune System
mice
Francisella tularensis
Virus Diseases
Infection
Mycobacterium tuberculosis
Bacterial Infections
Immune system
Respiratory System
Interferons
Human Influenza
macrophages
Morbidity
Mortality
Genes
cells

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Zinman, G., Brower-Sinning, R., Emeche, C. H., Ernst, J., Huang, G. T. W., Mahony, S., ... Morel, P. A. (2011). Large scale comparison of innate responses to viral and bacterial pathogens in mouse and macaque. PloS one, 6(7), [e22401]. https://doi.org/10.1371/journal.pone.0022401
Zinman, Guy ; Brower-Sinning, Rachel ; Emeche, Chineye H. ; Ernst, Jason ; Huang, Grace Tzu Wei ; Mahony, Shaun ; Myers, Amy J. ; O'Dee, Dawn M. ; Flynn, Jo Anne L. ; Nau, Gerard J. ; Ross, Ted M. ; Salter, Russell D. ; Benos, Panayiotis V. ; Bar Joseph, Ziv ; Morel, Penelope A. / Large scale comparison of innate responses to viral and bacterial pathogens in mouse and macaque. In: PloS one. 2011 ; Vol. 6, No. 7.
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abstract = "Viral and bacterial infections of the lower respiratory tract are major causes of morbidity and mortality worldwide. Alveolar macrophages line the alveolar spaces and are the first cells of the immune system to respond to invading pathogens. To determine the similarities and differences between the responses of mice and macaques to invading pathogens we profiled alveolar macrophages from these species following infection with two viral (PR8 and Fuj/02 influenza A) and two bacterial (Mycobacterium tuberculosis and Francisella tularensis Schu S4) pathogens. Cells were collected at 6 time points following each infection and expression profiles were compared across and between species. Our analyses identified a core set of genes, activated in both species and across all pathogens that were predominantly part of the interferon response pathway. In addition, we identified similarities across species in the way innate immune cells respond to lethal versus non-lethal pathogens. On the other hand we also found several species and pathogen specific response patterns. These results provide new insights into mechanisms by which the innate immune system responds to, and interacts with, invading pathogens.",
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Zinman, G, Brower-Sinning, R, Emeche, CH, Ernst, J, Huang, GTW, Mahony, S, Myers, AJ, O'Dee, DM, Flynn, JAL, Nau, GJ, Ross, TM, Salter, RD, Benos, PV, Bar Joseph, Z & Morel, PA 2011, 'Large scale comparison of innate responses to viral and bacterial pathogens in mouse and macaque', PloS one, vol. 6, no. 7, e22401. https://doi.org/10.1371/journal.pone.0022401

Large scale comparison of innate responses to viral and bacterial pathogens in mouse and macaque. / Zinman, Guy; Brower-Sinning, Rachel; Emeche, Chineye H.; Ernst, Jason; Huang, Grace Tzu Wei; Mahony, Shaun; Myers, Amy J.; O'Dee, Dawn M.; Flynn, Jo Anne L.; Nau, Gerard J.; Ross, Ted M.; Salter, Russell D.; Benos, Panayiotis V.; Bar Joseph, Ziv; Morel, Penelope A.

In: PloS one, Vol. 6, No. 7, e22401, 26.07.2011.

Research output: Contribution to journalArticle

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AU - Zinman, Guy

AU - Brower-Sinning, Rachel

AU - Emeche, Chineye H.

AU - Ernst, Jason

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AU - Mahony, Shaun

AU - Myers, Amy J.

AU - O'Dee, Dawn M.

AU - Flynn, Jo Anne L.

AU - Nau, Gerard J.

AU - Ross, Ted M.

AU - Salter, Russell D.

AU - Benos, Panayiotis V.

AU - Bar Joseph, Ziv

AU - Morel, Penelope A.

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N2 - Viral and bacterial infections of the lower respiratory tract are major causes of morbidity and mortality worldwide. Alveolar macrophages line the alveolar spaces and are the first cells of the immune system to respond to invading pathogens. To determine the similarities and differences between the responses of mice and macaques to invading pathogens we profiled alveolar macrophages from these species following infection with two viral (PR8 and Fuj/02 influenza A) and two bacterial (Mycobacterium tuberculosis and Francisella tularensis Schu S4) pathogens. Cells were collected at 6 time points following each infection and expression profiles were compared across and between species. Our analyses identified a core set of genes, activated in both species and across all pathogens that were predominantly part of the interferon response pathway. In addition, we identified similarities across species in the way innate immune cells respond to lethal versus non-lethal pathogens. On the other hand we also found several species and pathogen specific response patterns. These results provide new insights into mechanisms by which the innate immune system responds to, and interacts with, invading pathogens.

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