Large scale comparison of innate responses to viral and bacterial pathogens in mouse and macaque

Guy Zinman, Rachel Brower-Sinning, Chineye H. Emeche, Jason Ernst, Grace Tzu Wei Huang, Shaun Mahony, Amy J. Myers, Dawn M. O'Dee, Jo Anne L. Flynn, Gerard J. Nau, Ted M. Ross, Russell D. Salter, Panayiotis V. Benos, Ziv Bar Joseph, Penelope A. Morel

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Viral and bacterial infections of the lower respiratory tract are major causes of morbidity and mortality worldwide. Alveolar macrophages line the alveolar spaces and are the first cells of the immune system to respond to invading pathogens. To determine the similarities and differences between the responses of mice and macaques to invading pathogens we profiled alveolar macrophages from these species following infection with two viral (PR8 and Fuj/02 influenza A) and two bacterial (Mycobacterium tuberculosis and Francisella tularensis Schu S4) pathogens. Cells were collected at 6 time points following each infection and expression profiles were compared across and between species. Our analyses identified a core set of genes, activated in both species and across all pathogens that were predominantly part of the interferon response pathway. In addition, we identified similarities across species in the way innate immune cells respond to lethal versus non-lethal pathogens. On the other hand we also found several species and pathogen specific response patterns. These results provide new insights into mechanisms by which the innate immune system responds to, and interacts with, invading pathogens.

Original languageEnglish (US)
Article numbere22401
JournalPloS one
Volume6
Issue number7
DOIs
StatePublished - 2011

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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