This paper reports a large-scale direct shear testing of tire-derived aggregates (TDA) of large sizes (25 to 75 mm). TDA are pieces of processed and shredded waste tires that can be used as lightweight and quick fills for embankments, subgrades, and retaining wall backfills. A large-scale direct shear apparatus was built to obtain the shear strength of the large-sized material. The shear box dimensions were 78 cm wide, 80 cm long, and 122 cm tall. The lower shear box was driven by a hydraulic piston, while the upper shear box remained stationary. The horizontal shear forces, shear displacements, and vertical forces were recorded by an automatic data acquisition system. Four normal loads were applied on the TDA to simulate overburden pressures of 24, 48, 96, and 144 kPa (or 500, 1000, 2000, and 3000 lb/ft2). Duplicate tests were performed to verify the repeatability. Under each normal stress, the shear stress vs. deformation curve was plotted, and the maximum shear stress was obtained. Mohr-Coulomb failure criterion was developed, and the cohesion and friction angle were obtained.