LASP1 is a HIF1α target gene critical for metastasis of pancreatic cancer

Tiansuo Zhao, He Ren, Jing Li, Jing Chen, Huan Zhang, Wen Xin, Yan Sun, Lei Sun, Yongwei Yang, Junwei Sun, Xiuchao Wang, Song Gao, Chongbiao Huang, Huafeng Zhang, Shengyu Yang, Jihui Hao

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

LASP1 is an actin-binding protein associated with actin assembly dynamics in cancer cells.Here,wereport that LASP1 is overexpressed in pancreatic ductal adenocarcinoma (PDAC) where it promotes invasion and metastasis. We found that LASP1 overexpression in PDAC cells was mediated by HIF1α through direct binding to a hypoxia response element in the LASP1 promoter. HIF1α stimulated LASP1 expression in PDAC cells in vitro and mouse tumor xenografts in vivo. Clinically, LASP1 overexpression in PDAC patient specimens was associated significantly with lymph node metastasis and overall survival. Overall, our results defined LASP1 as a direct target gene for HIF1α upregulation that is critical for metastatic progression of PDAC.

Original languageEnglish (US)
Pages (from-to)111-119
Number of pages9
JournalCancer Research
Volume75
Issue number1
DOIs
StatePublished - Jan 1 2015

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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