Late Closure of the Ductus Arteriosus Using Indomethacin in the Preterm Infant

Mitchell Kresch, Fernando R. Moya, Robert J. Ascuitto, Nancy T. Ross-Ascuitto, Felipe Heusser

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Several studies have shown a lack of effect of indomethacin therapy for the closure of a patent ductus arteriosus (PDA) in premature infants over 14 days of postnatal age. In this report we describe two cases in which a hemodynamically significant PDA was closed with indomethacin in preterm infants over 20 days of age. The response to indomethacin may be more related to postconceptual age than to actual postnatal age. We suggest that intravenous indomethacin therapy should be attempted before surgical ligation is performed in those premature infants under 34 weeks postconceptual age who have a hemodynamically significant patent ductus arteriosus.

Original languageEnglish (US)
Pages (from-to)140-143
Number of pages4
JournalClinical Pediatrics
Volume27
Issue number3
DOIs
StatePublished - Jan 1 1988

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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