Late graft failure due to dual bone marrow infection with variants A and B of human Herpesvirus-6

C. S. Rosenfeld, W. B. Rybka, D. Weinbaum, D. R. Carrigan, K. K. Knox, D. F. Andrews, R. K. Shadduck

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Abstract

Hematopoietic effects of human Herpesvirus-6 (HHV-6) infection following bone marrow transplantation (BMT) include delayed engraftment and early myelosuppression. Variant A has not been isolated after BMT. A case of graft failure is reported following an HLA-identical BMT for chronic myelogenous leukemia (CML) in chronic phase. Evaluation of bone marrow during the period of graft failure revealed variants A and B of HHV-6 by culture, immunofluorescence, polymerase chain reaction (PCR), and immunohistochemistry. Evidence for other cases of graft failure, including cytomegalovirus (CMV), could not be found. A hypothesis is proposed that late graft failure in this case was due to variant A of HHV-6.

Original languageEnglish (US)
Pages (from-to)626-629
Number of pages4
JournalExperimental Hematology
Volume23
Issue number7
StatePublished - Jan 1 1995

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Hematology
  • Genetics
  • Cell Biology
  • Cancer Research

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    Rosenfeld, C. S., Rybka, W. B., Weinbaum, D., Carrigan, D. R., Knox, K. K., Andrews, D. F., & Shadduck, R. K. (1995). Late graft failure due to dual bone marrow infection with variants A and B of human Herpesvirus-6. Experimental Hematology, 23(7), 626-629.