Late graft failure due to dual bone marrow infection with variants A and B of human Herpesvirus-6

C. S. Rosenfeld, W. B. Rybka, D. Weinbaum, D. R. Carrigan, K. K. Knox, D. F. Andrews, R. K. Shadduck

Research output: Contribution to journalArticle

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Abstract

Hematopoietic effects of human Herpesvirus-6 (HHV-6) infection following bone marrow transplantation (BMT) include delayed engraftment and early myelosuppression. Variant A has not been isolated after BMT. A case of graft failure is reported following an HLA-identical BMT for chronic myelogenous leukemia (CML) in chronic phase. Evaluation of bone marrow during the period of graft failure revealed variants A and B of HHV-6 by culture, immunofluorescence, polymerase chain reaction (PCR), and immunohistochemistry. Evidence for other cases of graft failure, including cytomegalovirus (CMV), could not be found. A hypothesis is proposed that late graft failure in this case was due to variant A of HHV-6.

Original languageEnglish (US)
Pages (from-to)626-629
Number of pages4
JournalExperimental Hematology
Volume23
Issue number7
StatePublished - Jan 1 1995

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Human Herpesvirus 6
Bone Marrow
Bone Marrow Transplantation
Transplants
Infection
Leukemia, Myeloid, Chronic Phase
Herpesviridae Infections
Cytomegalovirus
Fluorescent Antibody Technique
Immunohistochemistry
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Hematology
  • Genetics
  • Cell Biology
  • Cancer Research

Cite this

Rosenfeld, C. S., Rybka, W. B., Weinbaum, D., Carrigan, D. R., Knox, K. K., Andrews, D. F., & Shadduck, R. K. (1995). Late graft failure due to dual bone marrow infection with variants A and B of human Herpesvirus-6. Experimental Hematology, 23(7), 626-629.
Rosenfeld, C. S. ; Rybka, W. B. ; Weinbaum, D. ; Carrigan, D. R. ; Knox, K. K. ; Andrews, D. F. ; Shadduck, R. K. / Late graft failure due to dual bone marrow infection with variants A and B of human Herpesvirus-6. In: Experimental Hematology. 1995 ; Vol. 23, No. 7. pp. 626-629.
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Rosenfeld, CS, Rybka, WB, Weinbaum, D, Carrigan, DR, Knox, KK, Andrews, DF & Shadduck, RK 1995, 'Late graft failure due to dual bone marrow infection with variants A and B of human Herpesvirus-6', Experimental Hematology, vol. 23, no. 7, pp. 626-629.

Late graft failure due to dual bone marrow infection with variants A and B of human Herpesvirus-6. / Rosenfeld, C. S.; Rybka, W. B.; Weinbaum, D.; Carrigan, D. R.; Knox, K. K.; Andrews, D. F.; Shadduck, R. K.

In: Experimental Hematology, Vol. 23, No. 7, 01.01.1995, p. 626-629.

Research output: Contribution to journalArticle

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AU - Rosenfeld, C. S.

AU - Rybka, W. B.

AU - Weinbaum, D.

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AU - Knox, K. K.

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AU - Shadduck, R. K.

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AB - Hematopoietic effects of human Herpesvirus-6 (HHV-6) infection following bone marrow transplantation (BMT) include delayed engraftment and early myelosuppression. Variant A has not been isolated after BMT. A case of graft failure is reported following an HLA-identical BMT for chronic myelogenous leukemia (CML) in chronic phase. Evaluation of bone marrow during the period of graft failure revealed variants A and B of HHV-6 by culture, immunofluorescence, polymerase chain reaction (PCR), and immunohistochemistry. Evidence for other cases of graft failure, including cytomegalovirus (CMV), could not be found. A hypothesis is proposed that late graft failure in this case was due to variant A of HHV-6.

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Rosenfeld CS, Rybka WB, Weinbaum D, Carrigan DR, Knox KK, Andrews DF et al. Late graft failure due to dual bone marrow infection with variants A and B of human Herpesvirus-6. Experimental Hematology. 1995 Jan 1;23(7):626-629.