Lead exposure during infancy permanently increases lithium-induced polydipsia

Richard B. Mailman, Martin R. Krigman, Robert A. Mueller, Paul Mushak, George R. Breese

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13 Scopus citations

Abstract

Lead (200 milligrams per kilogram) was administered daily by intubation to Long-Evans rats on days 3 through 30 of life. Thirty to 180 days after cessation of lead administration, the lead-treated rats were consistently more polydipsic after lithium administration (2 millimoles per kilogram per day) than were pair-treated controls. Lithium increased the plasma renin activity equally in both the lead-treated and the control groups. These data are evidence that there may be permanent neural changes induced by postnatal exposure to lead that are manifested by pharmacological challenge with lithium.

Original languageEnglish (US)
Pages (from-to)637-639
Number of pages3
JournalScience
Volume201
Issue number4356
DOIs
StatePublished - Jan 1 1978

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All Science Journal Classification (ASJC) codes

  • General

Cite this

Mailman, R. B., Krigman, M. R., Mueller, R. A., Mushak, P., & Breese, G. R. (1978). Lead exposure during infancy permanently increases lithium-induced polydipsia. Science, 201(4356), 637-639. https://doi.org/10.1126/science.675249