Left atrial appendage occlusion for stroke prevention in patients with atrial fibrillation

Rizma Jalees Bajwa, Lara Kovell, Jon R. Resar, Armin Arbab-Zadeh, Kaushik Mandal, Hugh Calkins, Ronald D. Berger

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Atrial fibrillation (AF) is a commonly sustained atrial arrhythmia with associated morbidity and mortality. AF is associated with increased risk of thromboembolism and stroke, requiring use of anticoagulation. Anticoagulation decreases the risk of stroke but is associated with a higher risk of bleeding, necessitating discontinuation in some patients. The left atrial appendage is the likely source of thrombus in the majority of patients with AF. This has led to the development of left atrial appendage occlusion as a means to reduce stroke risk in patients who have a contraindication to long-term anticoagulation. Multiple implantable devices have surfaced in the last few years, with some promising prospects. The main purpose of this review is to highlight the indications and use of these devices for left atrial appendage occlusion.

Original languageEnglish (US)
Pages (from-to)825-831
Number of pages7
JournalClinical Cardiology
Volume40
Issue number10
DOIs
StatePublished - Oct 1 2017

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Atrial Appendage
Atrial Fibrillation
Stroke
Equipment and Supplies
Thromboembolism
Cardiac Arrhythmias
Thrombosis
Hemorrhage
Morbidity
Mortality

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Bajwa, R. J., Kovell, L., Resar, J. R., Arbab-Zadeh, A., Mandal, K., Calkins, H., & Berger, R. D. (2017). Left atrial appendage occlusion for stroke prevention in patients with atrial fibrillation. Clinical Cardiology, 40(10), 825-831. https://doi.org/10.1002/clc.22764
Bajwa, Rizma Jalees ; Kovell, Lara ; Resar, Jon R. ; Arbab-Zadeh, Armin ; Mandal, Kaushik ; Calkins, Hugh ; Berger, Ronald D. / Left atrial appendage occlusion for stroke prevention in patients with atrial fibrillation. In: Clinical Cardiology. 2017 ; Vol. 40, No. 10. pp. 825-831.
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Bajwa, RJ, Kovell, L, Resar, JR, Arbab-Zadeh, A, Mandal, K, Calkins, H & Berger, RD 2017, 'Left atrial appendage occlusion for stroke prevention in patients with atrial fibrillation', Clinical Cardiology, vol. 40, no. 10, pp. 825-831. https://doi.org/10.1002/clc.22764

Left atrial appendage occlusion for stroke prevention in patients with atrial fibrillation. / Bajwa, Rizma Jalees; Kovell, Lara; Resar, Jon R.; Arbab-Zadeh, Armin; Mandal, Kaushik; Calkins, Hugh; Berger, Ronald D.

In: Clinical Cardiology, Vol. 40, No. 10, 01.10.2017, p. 825-831.

Research output: Contribution to journalReview article

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AU - Bajwa, Rizma Jalees

AU - Kovell, Lara

AU - Resar, Jon R.

AU - Arbab-Zadeh, Armin

AU - Mandal, Kaushik

AU - Calkins, Hugh

AU - Berger, Ronald D.

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AB - Atrial fibrillation (AF) is a commonly sustained atrial arrhythmia with associated morbidity and mortality. AF is associated with increased risk of thromboembolism and stroke, requiring use of anticoagulation. Anticoagulation decreases the risk of stroke but is associated with a higher risk of bleeding, necessitating discontinuation in some patients. The left atrial appendage is the likely source of thrombus in the majority of patients with AF. This has led to the development of left atrial appendage occlusion as a means to reduce stroke risk in patients who have a contraindication to long-term anticoagulation. Multiple implantable devices have surfaced in the last few years, with some promising prospects. The main purpose of this review is to highlight the indications and use of these devices for left atrial appendage occlusion.

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