Leg vasoconstriction during dynamic exercise with reduced cardiac output

James Anthony Pawelczyk, B. Hanel, R. A. Pawelczyk, J. Warberg, N. H. Secher

Research output: Contribution to journalArticle

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Abstract

We evaluated whether a reduction in cardiac output during dynamic exercise results in vasoconstriction of active skeletal muscle vasculature. Nine subject performed four 8-min bouts of cycling exercise at 71 ± 12 to 145 ± 13 W (40-84% maximal oxygen uptake). Exercise was reported after cardioselective (β1) adrenergic blockade (0.2 mg/kg metoprolol iv). Leg blood flow and cardiac output were determined with bolus injections of indocyanine green. Femoral arterial and venous pressures were monitored for measurement of heart rate, mean arterial pressure, and calculation of systemic and leg vascular conductance. Leg norepinephrine spillover was used as an index of regional sympathetic activity. During control, the highest heart rate and cardiac output were 171 ± 3 beats/min and 18.9 ± 0.9 l/min, respectively. β1-Blockade reduced these values to 147 ± 6 beats/min and 15.3 ± 0.9 l/min, respectively (P < 0.001). Mean arterial pressure was lower than control during light exercise with β1-blockade but did not differ from control with greater exercise intensities. At the highest work rate in the control condition, leg blood flow and vascular conductance were 5.4 ± 0.3 l/min and 5.2 ± 0.3 cl · min-1 · mmHg-1, respectively, and were reduced during β1-blockade to 4.8 ± 0.4 l/min (P < 0.01) and 4.6 ± 0.4 cl · min-1 · mmHg-1 (P < 0.05). During the same exercise condition leg norepinephrine spillover increased from a control value of 2.64 ± 1.16 to 5.62 ± 2.13 nM/min with β1-blockade (P < 0.05). At least one-third of the increase in mean arterial pressure during exercise with β1-blockade could be accounted for by leg vasoconstriction. We concluded that neurogenic vasoconstriction of active skeletal muscle can offset metabolic vasodilation during intense dynamic exercise when cardiac output is compromised.

Original languageEnglish (US)
Pages (from-to)1838-1846
Number of pages9
JournalJournal of Applied Physiology
Volume73
Issue number5
StatePublished - 1992

Fingerprint

Vasoconstriction
Cardiac Output
Leg
Arterial Pressure
Blood Vessels
Norepinephrine
Skeletal Muscle
Heart Rate
Metoprolol
Indocyanine Green
Venous Pressure
Thigh
Vasodilation
Adrenergic Agents
Oxygen
Light
Injections

All Science Journal Classification (ASJC) codes

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Pawelczyk, J. A., Hanel, B., Pawelczyk, R. A., Warberg, J., & Secher, N. H. (1992). Leg vasoconstriction during dynamic exercise with reduced cardiac output. Journal of Applied Physiology, 73(5), 1838-1846.
Pawelczyk, James Anthony ; Hanel, B. ; Pawelczyk, R. A. ; Warberg, J. ; Secher, N. H. / Leg vasoconstriction during dynamic exercise with reduced cardiac output. In: Journal of Applied Physiology. 1992 ; Vol. 73, No. 5. pp. 1838-1846.
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Pawelczyk, JA, Hanel, B, Pawelczyk, RA, Warberg, J & Secher, NH 1992, 'Leg vasoconstriction during dynamic exercise with reduced cardiac output', Journal of Applied Physiology, vol. 73, no. 5, pp. 1838-1846.

Leg vasoconstriction during dynamic exercise with reduced cardiac output. / Pawelczyk, James Anthony; Hanel, B.; Pawelczyk, R. A.; Warberg, J.; Secher, N. H.

In: Journal of Applied Physiology, Vol. 73, No. 5, 1992, p. 1838-1846.

Research output: Contribution to journalArticle

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T1 - Leg vasoconstriction during dynamic exercise with reduced cardiac output

AU - Pawelczyk, James Anthony

AU - Hanel, B.

AU - Pawelczyk, R. A.

AU - Warberg, J.

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N2 - We evaluated whether a reduction in cardiac output during dynamic exercise results in vasoconstriction of active skeletal muscle vasculature. Nine subject performed four 8-min bouts of cycling exercise at 71 ± 12 to 145 ± 13 W (40-84% maximal oxygen uptake). Exercise was reported after cardioselective (β1) adrenergic blockade (0.2 mg/kg metoprolol iv). Leg blood flow and cardiac output were determined with bolus injections of indocyanine green. Femoral arterial and venous pressures were monitored for measurement of heart rate, mean arterial pressure, and calculation of systemic and leg vascular conductance. Leg norepinephrine spillover was used as an index of regional sympathetic activity. During control, the highest heart rate and cardiac output were 171 ± 3 beats/min and 18.9 ± 0.9 l/min, respectively. β1-Blockade reduced these values to 147 ± 6 beats/min and 15.3 ± 0.9 l/min, respectively (P < 0.001). Mean arterial pressure was lower than control during light exercise with β1-blockade but did not differ from control with greater exercise intensities. At the highest work rate in the control condition, leg blood flow and vascular conductance were 5.4 ± 0.3 l/min and 5.2 ± 0.3 cl · min-1 · mmHg-1, respectively, and were reduced during β1-blockade to 4.8 ± 0.4 l/min (P < 0.01) and 4.6 ± 0.4 cl · min-1 · mmHg-1 (P < 0.05). During the same exercise condition leg norepinephrine spillover increased from a control value of 2.64 ± 1.16 to 5.62 ± 2.13 nM/min with β1-blockade (P < 0.05). At least one-third of the increase in mean arterial pressure during exercise with β1-blockade could be accounted for by leg vasoconstriction. We concluded that neurogenic vasoconstriction of active skeletal muscle can offset metabolic vasodilation during intense dynamic exercise when cardiac output is compromised.

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