Less Common Colorectal Cancer Predisposition Syndromes

Thomas McGarrity, Christopher Amos

Research output: Contribution to journalReview article

Abstract

A variety of syndromes confer increased risk for intestinal polyp development, outside the more commonly occurring syndromes. Each of these uncommon syndromes predispose to pathognomonic histologies that are uncommonly observed. Accurate diagnosis of these syndromes is contingent on higher-level pathology review, evaluation of signs and symptoms beyond sole consideration of the polyps, and collection of a detailed family history. When a genetic mutation can be identified in the proband, the management of intestinal and extra-intestinal cancer screening can be more appropriately tailored.

Original languageEnglish (US)
Pages (from-to)647-661
Number of pages15
JournalSurgical Oncology Clinics of North America
Volume18
Issue number4
DOIs
StatePublished - Oct 1 2009

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Colorectal Neoplasms
Intestinal Polyps
Intestinal Neoplasms
Polyps
Early Detection of Cancer
Signs and Symptoms
Histology
Pathology
Mutation

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

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abstract = "A variety of syndromes confer increased risk for intestinal polyp development, outside the more commonly occurring syndromes. Each of these uncommon syndromes predispose to pathognomonic histologies that are uncommonly observed. Accurate diagnosis of these syndromes is contingent on higher-level pathology review, evaluation of signs and symptoms beyond sole consideration of the polyps, and collection of a detailed family history. When a genetic mutation can be identified in the proband, the management of intestinal and extra-intestinal cancer screening can be more appropriately tailored.",
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Less Common Colorectal Cancer Predisposition Syndromes. / McGarrity, Thomas; Amos, Christopher.

In: Surgical Oncology Clinics of North America, Vol. 18, No. 4, 01.10.2009, p. 647-661.

Research output: Contribution to journalReview article

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AU - Amos, Christopher

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N2 - A variety of syndromes confer increased risk for intestinal polyp development, outside the more commonly occurring syndromes. Each of these uncommon syndromes predispose to pathognomonic histologies that are uncommonly observed. Accurate diagnosis of these syndromes is contingent on higher-level pathology review, evaluation of signs and symptoms beyond sole consideration of the polyps, and collection of a detailed family history. When a genetic mutation can be identified in the proband, the management of intestinal and extra-intestinal cancer screening can be more appropriately tailored.

AB - A variety of syndromes confer increased risk for intestinal polyp development, outside the more commonly occurring syndromes. Each of these uncommon syndromes predispose to pathognomonic histologies that are uncommonly observed. Accurate diagnosis of these syndromes is contingent on higher-level pathology review, evaluation of signs and symptoms beyond sole consideration of the polyps, and collection of a detailed family history. When a genetic mutation can be identified in the proband, the management of intestinal and extra-intestinal cancer screening can be more appropriately tailored.

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