@article{a30a231be05e4ddbbd1d5a255f22fed0,
title = "Lessons learned from the INHANCE consortium: An overview of recent results on head and neck cancer",
abstract = "Objective: To summarize the latest evidence on head and neck cancer epidemiology from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Subjects and Methods: INHANCE was established in 2004 to elucidate the etiology of head and neck cancer through pooled analyses of individual-level data on a large scale. We summarize results from recent INHANCE-based publications updating our 2015 overview. Results: Seventeen papers were published between 2015 and May 2020. These studies further define the nature of risks associated with tobacco and alcohol, and occupational exposures on head and neck cancer. The beneficial effects on incidence of head and neck cancer were identified for good oral health, endogenous and exogenous hormonal factors, and selected aspects of diet related to fruit and vegetables. INHANCE has begun to develop risk prediction models and to pool follow-up data on their studies, finding that ~30% of cases had cancer recurrence and 9% second primary cancers, with overall- and disease-specific 5-year-survival of 51% and 57%, respectively. Conclusions: The number and importance of INHANCE scientific findings provides further evidence of the advantages of large-scale internationally collaborative projects and will support the development of prevention strategies.",
author = "{the INHANCE Consortium investigators} and Francesca Bravi and Lee, {Yuan Chin Amy} and Mia Hashibe and Paolo Boffetta and Conway, {David I.} and Monica Ferraroni and {La Vecchia}, Carlo and Valeria Edefonti and Antonio Agudo and Wolfgang Ahrens and Simone Benhamou and Stefania Boccia and Paul Brennan and Hermann Brenner and Gabriella Cadoni and Cristina Canova and Chu Chen and Chuang, {Shu Chun} and Curado, {Maria Paula} and {Dal Maso}, Luigino and Daudt, {Alexander W.} and Gypsyamber D'Souza and Eleonora Fabianova and Leticia Fernandez and Silvia Franceschi and Werner Garavello and Maura Gillison and Gross, {Neil D.} and Hayes, {Richard B.} and Claire Healy and Rolando Herrero and Ivana Holcatova and Karl Kelsey and Kristina Kjaerheim and Rosalina Koifman and Pagona Lagiou and Philip Lazarus and Fabio Levi and Guojun Li and Jolanta Lissowska and Daniele Luce and Macfarlane, {Gary J.} and Dana Mates and Keitaro Matsuo and Michael McClean and Ana Menezes and Gwenn Menvielle and Hal Morgenstern and Moyses, {Raquel A.} and Joshua Muscat",
note = "Funding Information: The authors would like to thank Xavier Castellsagu? who collected data in the IARC International Multicenter study and passed away in 2016. The INHANCE consortium and the single studies included were supported by grants from the: National Institutes of Health (NIH) [no grant number provided for the INHANCE Pooled Data Project and Intramural Research Program for the Puerto Rico study, grant numbers P01CA068384, K07CA104231 for the New York Multicenter study, grant numbers R01CA048996, R01DE012609 for the Seattle (1985-1995) study, grant number TW001500 for the Fogarty International Research Collaboration Award (FIRCA) supporting the Iowa study, grant number R01CA061188 for the North Carolina (1994-1997) study, grant numbers P01CA068384, K07CA104231, R01DE013158 for the Tampa study, grant numbers P50CA090388, R01DA011386, R03CA077954, T32CA009142, U01CA096134, R21ES011667 for the Los Angeles study, grant numbers R01CA078609, R01CA100679 for the Boston study, grant number R01CA051845 for the MSKCC study, grant number R01CA030022 for the Seattle-Leo study, grant number DE016631 and the Intramural Research Program for the Baltimore study];",
year = "2021",
month = jan,
doi = "10.1111/odi.13502",
language = "English (US)",
volume = "27",
pages = "73--93",
journal = "Oral Diseases",
issn = "1354-523X",
publisher = "Wiley-Blackwell",
number = "1",
}