Lethal Mutagenesis: Exploiting Error-Prone Replication of Riboviruses for Antiviral Therapy

Jason D. Graci, Craig Eugene Cameron

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Replication of RNA viruses is an errorâprone process leading to approximately one mutation per genome per replication. However, there is a maximum level of mutation, termed the error threshold, beyond which the error frequency is too great to support viability. This chapter examines the evidence supporting lethal mutagenesis in vitro and in vivo. Additionally, the impact of resistance and the challenges to development of clinically effective lethal mutagens are discussed.

Original languageEnglish (US)
Title of host publicationAntiviral Drug Discovery for Emerging Diseases and Bioterrorism Threats
PublisherJohn Wiley and Sons
Pages203-220
Number of pages18
ISBN (Print)0471668273, 9780471668275
DOIs
StatePublished - Jan 27 2005

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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    Graci, J. D., & Cameron, C. E. (2005). Lethal Mutagenesis: Exploiting Error-Prone Replication of Riboviruses for Antiviral Therapy. In Antiviral Drug Discovery for Emerging Diseases and Bioterrorism Threats (pp. 203-220). John Wiley and Sons. https://doi.org/10.1002/0471716715.ch9