Leukocyte-extracellular matrix and coagulation protein interactions on biomaterials

N. P. Ziats, J. K. Yun, S. Shah, J. M. Anderson

Research output: Contribution to conferencePaper

2 Scopus citations

Abstract

The adhesion of human neutrophils and monocytes on materials coated with a variety of extracellular matrix or coagulation proteins under static or mechanically strained conditions was evaluated. It was shown that some extracellular matrix proteins and coagulation proteins have antiadhesive properties for leukocytes. Type V collagen and both single chain and double chain forms of high molecular weight kininogen (HMWK) inhibited endothelial cell adhesion and growth. Most cell types were prevented from adhering to a great extent by HMWK. SC HMWK also showed antiadhesive properties for neutrophils. Cell adhesion was not affected considerably by cyclic strain.

Original languageEnglish (US)
Number of pages1
Publication statusPublished - Dec 1 1996
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996

Other

OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can
Period5/29/966/2/96

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All Science Journal Classification (ASJC) codes

  • Materials Science(all)

Cite this

Ziats, N. P., Yun, J. K., Shah, S., & Anderson, J. M. (1996). Leukocyte-extracellular matrix and coagulation protein interactions on biomaterials. Paper presented at Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can, .