Leukocyte relaxation properties

K. L. Sung, C. Dong, G. W. Schmid-Schönbein, S. Chien, R. Skalak

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Study of the mechanical properties of leukocytes is useful to understand their passage through narrow capillaries and interaction with other cells. Leukocytes are known to be viscoelastic and their properties have been established by micropipette aspiration techniques. Here, the recovery of leukocytes to their normal spherical form is studied after prolonged deformation in a pipette which is large enough to permit complete entry of the leukocyte. The recovery history is characterized by the time history of the major diameter (d1) and minor diameter (d2). When the cell is removed from the pipette, it shows initially a small rapid recoil followed by a slower asymptotic recovery to the spherical shape. In the presence of cell activation and formation of pseudopods, the time history for recovery is prolonged compared with passive cell recovery. If a protopod pre-existed during the holding period, the recovery only begins when the protopod starts to retract.

Original languageEnglish (US)
Pages (from-to)331-336
Number of pages6
JournalBiophysical journal
Issue number2
Publication statusPublished - Jan 1 1988


All Science Journal Classification (ASJC) codes

  • Biophysics

Cite this

Sung, K. L., Dong, C., Schmid-Schönbein, G. W., Chien, S., & Skalak, R. (1988). Leukocyte relaxation properties. Biophysical journal, 54(2), 331-336. https://doi.org/10.1016/S0006-3495(88)82963-1