TY - JOUR
T1 - Leukocyte traits and exposure to ambient particulate matter air pollution in the women’s health initiative and atherosclerosis risk in communities study
AU - Gondalia, Rahul
AU - Holliday, Katelyn M.
AU - Baldassari, Antoine
AU - Justice, Anne E.
AU - Stewart, James D.
AU - Liao, Duanping
AU - Yanosky, Jeff D.
AU - Engel, Stephanie M.
AU - Jordahl, Kristina M.
AU - Bhatti, Parveen
AU - Horvath, Steve
AU - Assimes, Themistocles L.
AU - Pankow, James S.
AU - Demerath, Ellen W.
AU - Guan, Weihua
AU - Fornage, Myriam
AU - Bressler, Jan
AU - North, Kari E.
AU - Conneely, Karen N.
AU - Li, Yun
AU - Hou, Lifang
AU - Baccarelli, Andrea A.
AU - Whitsel, Eric A.
N1 - Funding Information:
The authors thank the staff and participants of the ARIC study for their important contributions. The Atherosclerosis Risk in Communities study has been funded in whole or in part with Federal funds from the Department of Health and Human Services (DHHS), National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI) (contracts HHSN268201700001I, HHSN268201700002I, HHSN268201-700003I, HHSN268201700004I, and HHSN268201700005I). Funding was also supported by NHLBI through the American Recovery and Reinvestment Act of 2009 (ARRA) 5RC2HL102419 and National Institute of Neurological Disorders and Stroke R01NS087541. Data from the ARIC study are available on request at https://www2.cscc.unc.edu/aric/distribution-agreements.
Funding Information:
The WHI program is funded by the NHLBI through contracts HHSN268201100046C, HHSN268201100001C, HHSN26820-1100002C, HHSN268201100003C, HHSN268201100004C, and HHSN271201100004C. WHI-AS311 was supported by American Cancer Society award 125,299-RSG-13-100-01-CCE. All contributors to WHI science are listed at https://www.whi. org/researchers/Documents%20%20Write%20a%20Paper/WHI %20Investigator%20Long%20List.pdf. Data from the WHI are available on request at https://www.whi.org/researchers/SitePages/ Write%20a%20Paper.aspx.
Funding Information:
The authors thank the staff and participants of the ARIC study for their important contributions. The Atherosclerosis Risk in Communities study has been funded in whole or in part with Federal funds from the Department of Health and Human Services (DHHS), National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI) (contracts HHSN268201700001I, HHSN268201700002I, HHSN268201-700003I, HHSN268201700004I, and HHSN268201700005I). Funding was also supported by NHLBI through the American Recovery and Reinvestment Act of 2009 (ARRA) 5RC2HL102419 and National Institute of Neurological Disorders and Stroke R01NS087541. Data from the ARIC study are available on request at https://www2.cscc.unc.edu/aric/distribution-agreements. The WHI program is funded by the NHLBI through contracts HHSN268201100046C, HHSN268201100001C, HHSN26820-1100002C, HHSN268201100003C, HHSN268201100004C, and HHSN271201100004C. WHI-AS311 was supported by American Cancer Society award 125,299-RSG-13-100-01-CCE. All contributors to WHI science are listed at https://www.whi. org/researchers/Documents%20%20Write%20a%20Paper/WHI %20Investigator%20Long%20List.pdf. Data from the WHI are available on request at https://www.whi.org/researchers/SitePages/ Write%20a%20Paper.aspx. This work was supported by the NIH/National Institute of Environmental Health Sciences (NIEHS) grant R01-ES020836 (L.H., A.B., E.A.W.), NHLBI contract HHSN268201100046C (K.N.C.), NIEHS grant R01-ES017794 (E.A.W.), NHLBI National Research Service Award T32-HL007055 (R.G.), NIEHS National Research Service Award T32-ES007018 (K.M.H.), and National Cancer Institute grant R25-CA094880 (K.M.J.).
Funding Information:
This work was supported by the NIH/National Institute of Environmental Health Sciences (NIEHS) grant R01-ES020836 (L.H., A.B., E.A.W.), NHLBI contract HHSN268201100046C (K.N.C.), NIEHS grant R01-ES017794 (E.A.W.), NHLBI National Research Service Award T32-HL007055 (R.G.), NIEHS National Research Service Award T32-ES007018 (K.M.H.), and National Cancer Institute grant R25-CA094880 (K.M.J.).
Publisher Copyright:
© 2020, Public Health Services, US Dept of Health and Human Services. All rights reserved.
PY - 2020/1
Y1 - 2020/1
N2 - BACKGROUND: Inflammatory effects of ambient particulate matter (PM) air pollution exposures may underlie PM-related increases in cardiovascular disease risk and mortality, although evidence of PM-associated leukocytosis is inconsistent and largely based on small, cross-sectional, and/or unrepresentative study populations. OBJECTIVES: Our objective was to estimate PM–leukocyte associations among U.S. women and men in the Women’s Health Initiative and Atherosclerosis Risk in Communities study (n = 165,675). METHODS: We based the PM–leukocyte estimations on up to four study visits per participant, at which peripheral blood leukocytes and geocoded address-specific concentrations of PM ≤ 10, ≤2:5, and 2:5–10 lm in diameter (PM10, PM2:5, and PM2:5–10, respectively) were available. We multiply imputed missing data using chained equations and estimated PM–leukocyte count associations over daily to yearly PM exposure averaging periods using center-specific, linear, mixed, longitudinal models weighted for attrition and adjusted for sociodemographic, behavioral, meteorological, and geographic covariates. In a subset of participants with available data (n = 8,457), we also estimated PM–leukocyte proportion associations in compositional data analyses. RESULTS: We found a 12 cells=lL (95% confidence interval: −9, 33) higher leukocyte count, a 1.2% (0.6%, 1.8%) higher granulocyte proportion, and a −1:1% (−1:9%, −0:3%) lower CD8+ T-cell proportion per 10-lg=m3 increase in 1-month mean PM2:5. However, shorter-duration PM10 exposures were inversely and only modestly associated with leukocyte count. DISCUSSION: The PM2:5 –leukocyte estimates, albeit imprecise, suggest that among racially, ethnically, and environmentally diverse U.S. populations, sustained, ambient exposure to fine PM may induce subclinical, but epidemiologically important, inflammatory effects. https://doi.org/10.1289/EHP5360.
AB - BACKGROUND: Inflammatory effects of ambient particulate matter (PM) air pollution exposures may underlie PM-related increases in cardiovascular disease risk and mortality, although evidence of PM-associated leukocytosis is inconsistent and largely based on small, cross-sectional, and/or unrepresentative study populations. OBJECTIVES: Our objective was to estimate PM–leukocyte associations among U.S. women and men in the Women’s Health Initiative and Atherosclerosis Risk in Communities study (n = 165,675). METHODS: We based the PM–leukocyte estimations on up to four study visits per participant, at which peripheral blood leukocytes and geocoded address-specific concentrations of PM ≤ 10, ≤2:5, and 2:5–10 lm in diameter (PM10, PM2:5, and PM2:5–10, respectively) were available. We multiply imputed missing data using chained equations and estimated PM–leukocyte count associations over daily to yearly PM exposure averaging periods using center-specific, linear, mixed, longitudinal models weighted for attrition and adjusted for sociodemographic, behavioral, meteorological, and geographic covariates. In a subset of participants with available data (n = 8,457), we also estimated PM–leukocyte proportion associations in compositional data analyses. RESULTS: We found a 12 cells=lL (95% confidence interval: −9, 33) higher leukocyte count, a 1.2% (0.6%, 1.8%) higher granulocyte proportion, and a −1:1% (−1:9%, −0:3%) lower CD8+ T-cell proportion per 10-lg=m3 increase in 1-month mean PM2:5. However, shorter-duration PM10 exposures were inversely and only modestly associated with leukocyte count. DISCUSSION: The PM2:5 –leukocyte estimates, albeit imprecise, suggest that among racially, ethnically, and environmentally diverse U.S. populations, sustained, ambient exposure to fine PM may induce subclinical, but epidemiologically important, inflammatory effects. https://doi.org/10.1289/EHP5360.
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U2 - 10.1289/EHP5360
DO - 10.1289/EHP5360
M3 - Article
C2 - 31903802
AN - SCOPUS:85077480406
SN - 0091-6765
VL - 128
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
IS - 1
M1 - 017004
ER -