Levels of polychlorinated dibenzo‐p‐dioxins and dibenzofurans in workers exposed to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin

Donald George Jr Patterson, M. A. Fingerhut, D. W. Roberts, L. L. Needham, M. Haring Sweeney, D. A. Marlow, J. S. Andrews, W. E. Halperin

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Abstract

Review of employment and chemical production records at a Missouri chemical plant and of questionnaires with self‐reported occupational exposure to 2,3,7,8‐tetrachloro‐dibenzo‐p‐dioxin (2,3,7,8‐TCDD) for 16 Missouri workers has explained the wide diversity of 2,3,7,8‐TCDD levels previously reported in the workers' adipose tissue (3.5‐750 ppt on whole‐weight basis). We show that the highest exposures reported to date in the United States occurred in a group of nine production workers who made products contaminated with 2,3,7,8‐TCDD. The nine workers had adipose tissue levels with a mean of 246 ppt and a range of 42 to 750 ppt. Seven persons who worked at the same chemical company, but not in the 2,3,7,8‐TCDD‐contaminated process, had a mean of 8.7 ppt and a range of 3.5 to 25.8 ppt. We also report serum levels of 2,3,7,8‐TCDD in these individuals. The adipose tissue from a subset of four production workers with elevated levels of 2,3,7,8‐TCDD and seven Missouri residents with normal 2,3,7,8‐TCDD levels was also analyzed for other isomers of the PCDDs and PCDFs. The mean adipose tissue level of 2,3,7,8‐TCDD in the subset of production workers was 45 times higher than the mean level in the unexposed Missouri residents, but similar levels of the other PCDDs and PCDFs were found in both groups.

Original languageEnglish (US)
Pages (from-to)135-146
Number of pages12
JournalAmerican Journal of Industrial Medicine
Volume16
Issue number2
DOIs
StatePublished - Jan 1 1989

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Adipose Tissue
Occupational Exposure
Polychlorinated Dibenzofurans
Serum
Polychlorinated Dibenzodioxins

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

Patterson, D. G. J., Fingerhut, M. A., Roberts, D. W., Needham, L. L., Sweeney, M. H., Marlow, D. A., ... Halperin, W. E. (1989). Levels of polychlorinated dibenzo‐p‐dioxins and dibenzofurans in workers exposed to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin. American Journal of Industrial Medicine, 16(2), 135-146. https://doi.org/10.1002/ajim.4700160205
Patterson, Donald George Jr ; Fingerhut, M. A. ; Roberts, D. W. ; Needham, L. L. ; Sweeney, M. Haring ; Marlow, D. A. ; Andrews, J. S. ; Halperin, W. E. / Levels of polychlorinated dibenzo‐p‐dioxins and dibenzofurans in workers exposed to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin. In: American Journal of Industrial Medicine. 1989 ; Vol. 16, No. 2. pp. 135-146.
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abstract = "Review of employment and chemical production records at a Missouri chemical plant and of questionnaires with self‐reported occupational exposure to 2,3,7,8‐tetrachloro‐dibenzo‐p‐dioxin (2,3,7,8‐TCDD) for 16 Missouri workers has explained the wide diversity of 2,3,7,8‐TCDD levels previously reported in the workers' adipose tissue (3.5‐750 ppt on whole‐weight basis). We show that the highest exposures reported to date in the United States occurred in a group of nine production workers who made products contaminated with 2,3,7,8‐TCDD. The nine workers had adipose tissue levels with a mean of 246 ppt and a range of 42 to 750 ppt. Seven persons who worked at the same chemical company, but not in the 2,3,7,8‐TCDD‐contaminated process, had a mean of 8.7 ppt and a range of 3.5 to 25.8 ppt. We also report serum levels of 2,3,7,8‐TCDD in these individuals. The adipose tissue from a subset of four production workers with elevated levels of 2,3,7,8‐TCDD and seven Missouri residents with normal 2,3,7,8‐TCDD levels was also analyzed for other isomers of the PCDDs and PCDFs. The mean adipose tissue level of 2,3,7,8‐TCDD in the subset of production workers was 45 times higher than the mean level in the unexposed Missouri residents, but similar levels of the other PCDDs and PCDFs were found in both groups.",
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Patterson, DGJ, Fingerhut, MA, Roberts, DW, Needham, LL, Sweeney, MH, Marlow, DA, Andrews, JS & Halperin, WE 1989, 'Levels of polychlorinated dibenzo‐p‐dioxins and dibenzofurans in workers exposed to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin', American Journal of Industrial Medicine, vol. 16, no. 2, pp. 135-146. https://doi.org/10.1002/ajim.4700160205

Levels of polychlorinated dibenzo‐p‐dioxins and dibenzofurans in workers exposed to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin. / Patterson, Donald George Jr; Fingerhut, M. A.; Roberts, D. W.; Needham, L. L.; Sweeney, M. Haring; Marlow, D. A.; Andrews, J. S.; Halperin, W. E.

In: American Journal of Industrial Medicine, Vol. 16, No. 2, 01.01.1989, p. 135-146.

Research output: Contribution to journalArticle

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T1 - Levels of polychlorinated dibenzo‐p‐dioxins and dibenzofurans in workers exposed to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin

AU - Patterson, Donald George Jr

AU - Fingerhut, M. A.

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AU - Andrews, J. S.

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