Levemopamil injection after cerebral oligemia reduces spatial memory deficits in rats

Christine Heim, Maria Sieklucka, Karl Heinz Sontag

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Transient reduction of cerebral blood flow to oligemic levels as produced by bilateral clamping of carotid arteries (BCCA) in pentobarbital anesthetized Wistar rats leads to spatial orientation deficiencies in a water maze test 8-10 days after surgery. These deficiencies are more pronounced in 4-month-old than in 6-week-old animals. Levemopamil [(2S)-2-isopropyl-5-(methylphenethylamino)-2-phenylvaleronitrile hydrochloride], a Ca2+ channel blocker and 5-HT2 antagonist, prevents the deficiencies in groups of animals of both ages, even when administered 24 h after the transient vessel occlusion. Levemopamil did not influence the maze performance of sham-operated control rats. Levemopamil, therefore, appears to modulate mechanisms that are altered specifically either by, or as a consequence of, the BCCA procedure. Levemopamil did not influence the altered GABA or ACh content in different vulnerable brain structures following BCCA, showing that the substance acts via additional mechanisms affected by the BCCA procedure.

Original languageEnglish (US)
Pages (from-to)613-619
Number of pages7
JournalPharmacology, Biochemistry and Behavior
Volume48
Issue number3
DOIs
StatePublished - Jul 1994

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Fingerprint Dive into the research topics of 'Levemopamil injection after cerebral oligemia reduces spatial memory deficits in rats'. Together they form a unique fingerprint.

Cite this