Lidocaine decay and hepatic extraction in the Pig

B. METS, R. ALLIN, J. VAN DYKE, R. HICKMAN

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Plasma lidocaine decay after injection was studied in five anaesthetized pigs and fitted to a two compartment open model. Derived pharniacokinetic paranieter‐s were eniployed to rapidly achieve plateau concentrations within 60 min of starting a two stage infusion of lidocaine hydrochloride. Hepatic extraction and clearance of lidocaine at steady state were determined in 10 pigs by transhep;ttic: sampling and nieasurenient of hepatic arterial and portal venous blood flow using perivascular ultrasonic flow probes placed at laparotomy. These data were compared with siniilar studies performed in man as well as the sheep, (log, monkey and cat. The lidocaine extraction ratio of 0.60 in the pig was found t o be similar to that determined by others in man.

Original languageEnglish (US)
Pages (from-to)8-14
Number of pages7
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume16
Issue number1
DOIs
StatePublished - Mar 1993

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • veterinary(all)

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