Plasma lidocaine decay after injection was studied in five anaesthetized pigs and fitted to a two compartment open model. Derived pharniacokinetic paranieter‐s were eniployed to rapidly achieve plateau concentrations within 60 min of starting a two stage infusion of lidocaine hydrochloride. Hepatic extraction and clearance of lidocaine at steady state were determined in 10 pigs by transhep;ttic: sampling and nieasurenient of hepatic arterial and portal venous blood flow using perivascular ultrasonic flow probes placed at laparotomy. These data were compared with siniilar studies performed in man as well as the sheep, (log, monkey and cat. The lidocaine extraction ratio of 0.60 in the pig was found t o be similar to that determined by others in man.
|Original language||English (US)|
|Number of pages||7|
|Journal||Journal of Veterinary Pharmacology and Therapeutics|
|State||Published - Mar 1993|
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