Life after surgical resection of a meningioma: A prospective cross-sectional study evaluating health-related quality of life

International Consortium on Meningiomas

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Abstract

Background Few studies have evaluated the health-related quality of life (HRQoL) of patients with meningiomas. Here, we report the largest prospective, longitudinal cross-sectional cohort study of HRQoL in meningiomas to date, in order to identify possible actionable determinants of global HRQoL. Methods Adults who had undergone resection of a grade I intracranial meningioma and were in routine follow-up at a single large tertiary center underwent HRQoL assessment using the QLQ-C30 questionnaire administered opportunistically at follow-up visits. Averaged transformed QLQ-C30 scores at 12-month intervals were compared with scores from a normative reference population, with reference to known minimal clinically meaningful difference (CMD) in scores. To evaluate for possible determinants of changes in global HRQoL, global HRQoL scores were correlated (Spearman's Rho) with subdomain and symptom scores and with interval time from surgical resection. Results A total of 291 postoperative patients with histologically confirmed and surgically treated grade I meningiomas consented to participation and a total of 455 questionnaires were included for analysis. Patients with meningiomas reported reduced global HRQoL at nearly every 12-month interval with clinically and statistically significant impairments at 12, 48, 108, and 120 months postoperative compared with the normative population (P < 0.05). Meningioma patients at the 12-month interval also reported a reduction of each subdomain of HRQoL assessment (P < 0.05); however, a CMD was only seen in cognitive functioning. Physical, emotional, cognitive, and social subdomains, as well as fatigue and sleep/insomnia, were significantly associated with global HRQoL at the first 12-month interval. Overall, there was no significant correlation between time from surgery and global HRQoL or the subdomain functional or symptom sections of the QLQ-C30. Conclusions Meningioma patients report considerable limitations in HRQoL for more than 120 months after surgery, particularly in cognitive, emotional, and social function, as well as suffering significant fatigue and sleep impairment compared with a normative reference population. The majority of these reported functional impairments and symptoms are strongly associated with global HRQoL and thus can be considered determinants of global HRQoL that if treated, have the potential to improve HRQoL for our meningioma patients. This hypothesis requires future study of targeted interventions to determine their efficacy.

Original languageEnglish (US)
Pages (from-to)I32-I43
JournalNeuro-oncology
Volume21
DOIs
StatePublished - Jan 14 2019

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Meningioma
Cross-Sectional Studies
Quality of Life
Fatigue
Sleep
Population
Global Health
Sleep Initiation and Maintenance Disorders
Cohort Studies

All Science Journal Classification (ASJC) codes

  • Oncology
  • Clinical Neurology
  • Cancer Research

Cite this

@article{e3fe0c06ca1c4f4d80424a72ba6f1c40,
title = "Life after surgical resection of a meningioma: A prospective cross-sectional study evaluating health-related quality of life",
abstract = "Background Few studies have evaluated the health-related quality of life (HRQoL) of patients with meningiomas. Here, we report the largest prospective, longitudinal cross-sectional cohort study of HRQoL in meningiomas to date, in order to identify possible actionable determinants of global HRQoL. Methods Adults who had undergone resection of a grade I intracranial meningioma and were in routine follow-up at a single large tertiary center underwent HRQoL assessment using the QLQ-C30 questionnaire administered opportunistically at follow-up visits. Averaged transformed QLQ-C30 scores at 12-month intervals were compared with scores from a normative reference population, with reference to known minimal clinically meaningful difference (CMD) in scores. To evaluate for possible determinants of changes in global HRQoL, global HRQoL scores were correlated (Spearman's Rho) with subdomain and symptom scores and with interval time from surgical resection. Results A total of 291 postoperative patients with histologically confirmed and surgically treated grade I meningiomas consented to participation and a total of 455 questionnaires were included for analysis. Patients with meningiomas reported reduced global HRQoL at nearly every 12-month interval with clinically and statistically significant impairments at 12, 48, 108, and 120 months postoperative compared with the normative population (P < 0.05). Meningioma patients at the 12-month interval also reported a reduction of each subdomain of HRQoL assessment (P < 0.05); however, a CMD was only seen in cognitive functioning. Physical, emotional, cognitive, and social subdomains, as well as fatigue and sleep/insomnia, were significantly associated with global HRQoL at the first 12-month interval. Overall, there was no significant correlation between time from surgery and global HRQoL or the subdomain functional or symptom sections of the QLQ-C30. Conclusions Meningioma patients report considerable limitations in HRQoL for more than 120 months after surgery, particularly in cognitive, emotional, and social function, as well as suffering significant fatigue and sleep impairment compared with a normative reference population. The majority of these reported functional impairments and symptoms are strongly associated with global HRQoL and thus can be considered determinants of global HRQoL that if treated, have the potential to improve HRQoL for our meningioma patients. This hypothesis requires future study of targeted interventions to determine their efficacy.",
author = "{International Consortium on Meningiomas} and Farshad Nassiri and Benjamin Price and Ameer Shehab and Karolyn Au and Cusimano, {Michael D.} and Jenkinson, {Michael D.} and Christine Jungk and Mansouri, {Seyed Alireza} and Thomas Santarius and Suganth Suppiah and Teng, {Ken X.} and Toor, {Gurvinder S.} and Gelareh Zadeh and Tobias Walbert and Drummond, {Katharine J.} and Kenneth Aldape and Jill Barnhartz-Sloan and Bi, {Wenya Linda} and Brastianos, {Priscilla K.} and Nicholas Butowski and Carlos Carlotti and Francesco Dimeco and Dunn, {Ian F.} and Evanthia Galanis and Caterina Giannini and Roland Goldbrunner and Brent Griffith and Rintaro Hashizume and Hanemann, {C. Oliver} and Christel Herold-Mende and Craig Horbinski and Huang, {Raymond Y.} and David James and Kaufman, {Timothy J.} and Boris Krischek and Daniel Lachance and Christian Lafoug{\`e}re and Ian Lee and Liu, {Jeff C.} and Yasin Mamatjan and Christian Mawrin and Michael McDermott and David Munoz and Houtan Noushmehr and Ng, {Ho Keung} and Arie Perry and Farhad Pirouzmand and Poisson, {Laila M.} and Bianca Pollo and David Raleigh",
year = "2019",
month = "1",
day = "14",
doi = "10.1093/neuonc/noy152",
language = "English (US)",
volume = "21",
pages = "I32--I43",
journal = "Neuro-Oncology",
issn = "1522-8517",
publisher = "Oxford University Press",

}

Life after surgical resection of a meningioma : A prospective cross-sectional study evaluating health-related quality of life. / International Consortium on Meningiomas.

In: Neuro-oncology, Vol. 21, 14.01.2019, p. I32-I43.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Life after surgical resection of a meningioma

T2 - A prospective cross-sectional study evaluating health-related quality of life

AU - International Consortium on Meningiomas

AU - Nassiri, Farshad

AU - Price, Benjamin

AU - Shehab, Ameer

AU - Au, Karolyn

AU - Cusimano, Michael D.

AU - Jenkinson, Michael D.

AU - Jungk, Christine

AU - Mansouri, Seyed Alireza

AU - Santarius, Thomas

AU - Suppiah, Suganth

AU - Teng, Ken X.

AU - Toor, Gurvinder S.

AU - Zadeh, Gelareh

AU - Walbert, Tobias

AU - Drummond, Katharine J.

AU - Aldape, Kenneth

AU - Barnhartz-Sloan, Jill

AU - Bi, Wenya Linda

AU - Brastianos, Priscilla K.

AU - Butowski, Nicholas

AU - Carlotti, Carlos

AU - Dimeco, Francesco

AU - Dunn, Ian F.

AU - Galanis, Evanthia

AU - Giannini, Caterina

AU - Goldbrunner, Roland

AU - Griffith, Brent

AU - Hashizume, Rintaro

AU - Hanemann, C. Oliver

AU - Herold-Mende, Christel

AU - Horbinski, Craig

AU - Huang, Raymond Y.

AU - James, David

AU - Kaufman, Timothy J.

AU - Krischek, Boris

AU - Lachance, Daniel

AU - Lafougère, Christian

AU - Lee, Ian

AU - Liu, Jeff C.

AU - Mamatjan, Yasin

AU - Mawrin, Christian

AU - McDermott, Michael

AU - Munoz, David

AU - Noushmehr, Houtan

AU - Ng, Ho Keung

AU - Perry, Arie

AU - Pirouzmand, Farhad

AU - Poisson, Laila M.

AU - Pollo, Bianca

AU - Raleigh, David

PY - 2019/1/14

Y1 - 2019/1/14

N2 - Background Few studies have evaluated the health-related quality of life (HRQoL) of patients with meningiomas. Here, we report the largest prospective, longitudinal cross-sectional cohort study of HRQoL in meningiomas to date, in order to identify possible actionable determinants of global HRQoL. Methods Adults who had undergone resection of a grade I intracranial meningioma and were in routine follow-up at a single large tertiary center underwent HRQoL assessment using the QLQ-C30 questionnaire administered opportunistically at follow-up visits. Averaged transformed QLQ-C30 scores at 12-month intervals were compared with scores from a normative reference population, with reference to known minimal clinically meaningful difference (CMD) in scores. To evaluate for possible determinants of changes in global HRQoL, global HRQoL scores were correlated (Spearman's Rho) with subdomain and symptom scores and with interval time from surgical resection. Results A total of 291 postoperative patients with histologically confirmed and surgically treated grade I meningiomas consented to participation and a total of 455 questionnaires were included for analysis. Patients with meningiomas reported reduced global HRQoL at nearly every 12-month interval with clinically and statistically significant impairments at 12, 48, 108, and 120 months postoperative compared with the normative population (P < 0.05). Meningioma patients at the 12-month interval also reported a reduction of each subdomain of HRQoL assessment (P < 0.05); however, a CMD was only seen in cognitive functioning. Physical, emotional, cognitive, and social subdomains, as well as fatigue and sleep/insomnia, were significantly associated with global HRQoL at the first 12-month interval. Overall, there was no significant correlation between time from surgery and global HRQoL or the subdomain functional or symptom sections of the QLQ-C30. Conclusions Meningioma patients report considerable limitations in HRQoL for more than 120 months after surgery, particularly in cognitive, emotional, and social function, as well as suffering significant fatigue and sleep impairment compared with a normative reference population. The majority of these reported functional impairments and symptoms are strongly associated with global HRQoL and thus can be considered determinants of global HRQoL that if treated, have the potential to improve HRQoL for our meningioma patients. This hypothesis requires future study of targeted interventions to determine their efficacy.

AB - Background Few studies have evaluated the health-related quality of life (HRQoL) of patients with meningiomas. Here, we report the largest prospective, longitudinal cross-sectional cohort study of HRQoL in meningiomas to date, in order to identify possible actionable determinants of global HRQoL. Methods Adults who had undergone resection of a grade I intracranial meningioma and were in routine follow-up at a single large tertiary center underwent HRQoL assessment using the QLQ-C30 questionnaire administered opportunistically at follow-up visits. Averaged transformed QLQ-C30 scores at 12-month intervals were compared with scores from a normative reference population, with reference to known minimal clinically meaningful difference (CMD) in scores. To evaluate for possible determinants of changes in global HRQoL, global HRQoL scores were correlated (Spearman's Rho) with subdomain and symptom scores and with interval time from surgical resection. Results A total of 291 postoperative patients with histologically confirmed and surgically treated grade I meningiomas consented to participation and a total of 455 questionnaires were included for analysis. Patients with meningiomas reported reduced global HRQoL at nearly every 12-month interval with clinically and statistically significant impairments at 12, 48, 108, and 120 months postoperative compared with the normative population (P < 0.05). Meningioma patients at the 12-month interval also reported a reduction of each subdomain of HRQoL assessment (P < 0.05); however, a CMD was only seen in cognitive functioning. Physical, emotional, cognitive, and social subdomains, as well as fatigue and sleep/insomnia, were significantly associated with global HRQoL at the first 12-month interval. Overall, there was no significant correlation between time from surgery and global HRQoL or the subdomain functional or symptom sections of the QLQ-C30. Conclusions Meningioma patients report considerable limitations in HRQoL for more than 120 months after surgery, particularly in cognitive, emotional, and social function, as well as suffering significant fatigue and sleep impairment compared with a normative reference population. The majority of these reported functional impairments and symptoms are strongly associated with global HRQoL and thus can be considered determinants of global HRQoL that if treated, have the potential to improve HRQoL for our meningioma patients. This hypothesis requires future study of targeted interventions to determine their efficacy.

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U2 - 10.1093/neuonc/noy152

DO - 10.1093/neuonc/noy152

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AN - SCOPUS:85060024897

VL - 21

SP - I32-I43

JO - Neuro-Oncology

JF - Neuro-Oncology

SN - 1522-8517

ER -