Life events, genetic susceptibility, and smoking among adolescents

Fred C. Pampel, Jason D. Boardman, Jonathan Daw, Michael C. Stallings, Andrew Smolen, Brett C. Haberstick, Keith F. Widaman, Tricia K. Neppl, Rand D. Conger

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Although stressful life events during adolescence are associated with the adoption of unhealthy behaviors such as smoking, both social circumstances and physical traits can moderate the relationship. This study builds on the stress paradigm and gene-environment approach to social behavior by examining how a polymorphism in the serotonin transporter gene 5-HTTLPR moderates the effect of life events on adolescent smoking. Tests of interaction hypotheses use data from the Family Transitions Project, a longitudinal study of 7th graders followed for 5. years. A sibling-pair design with separate models for the gender composition of pairs (brothers, sisters, or brother/sister) controls for unmeasured family background. The results show that negative life events are significantly and positively associated with smoking. Among brother pairs but not other pairs, the results provide evidence of gene-environment interaction by showing that life events more strongly influence smoking behavior for those with more copies of the 5-HTTLPR S allele.

Original languageEnglish (US)
Pages (from-to)221-232
Number of pages12
JournalSocial Science Research
Volume54
DOIs
StatePublished - Nov 1 2015

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smoking
adolescent
event
interaction
social behavior
adolescence
longitudinal study
paradigm
gender
evidence

All Science Journal Classification (ASJC) codes

  • Education
  • Sociology and Political Science

Cite this

Pampel, F. C., Boardman, J. D., Daw, J., Stallings, M. C., Smolen, A., Haberstick, B. C., ... Conger, R. D. (2015). Life events, genetic susceptibility, and smoking among adolescents. Social Science Research, 54, 221-232. https://doi.org/10.1016/j.ssresearch.2015.08.001
Pampel, Fred C. ; Boardman, Jason D. ; Daw, Jonathan ; Stallings, Michael C. ; Smolen, Andrew ; Haberstick, Brett C. ; Widaman, Keith F. ; Neppl, Tricia K. ; Conger, Rand D. / Life events, genetic susceptibility, and smoking among adolescents. In: Social Science Research. 2015 ; Vol. 54. pp. 221-232.
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Pampel, FC, Boardman, JD, Daw, J, Stallings, MC, Smolen, A, Haberstick, BC, Widaman, KF, Neppl, TK & Conger, RD 2015, 'Life events, genetic susceptibility, and smoking among adolescents', Social Science Research, vol. 54, pp. 221-232. https://doi.org/10.1016/j.ssresearch.2015.08.001

Life events, genetic susceptibility, and smoking among adolescents. / Pampel, Fred C.; Boardman, Jason D.; Daw, Jonathan; Stallings, Michael C.; Smolen, Andrew; Haberstick, Brett C.; Widaman, Keith F.; Neppl, Tricia K.; Conger, Rand D.

In: Social Science Research, Vol. 54, 01.11.2015, p. 221-232.

Research output: Contribution to journalArticle

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Pampel FC, Boardman JD, Daw J, Stallings MC, Smolen A, Haberstick BC et al. Life events, genetic susceptibility, and smoking among adolescents. Social Science Research. 2015 Nov 1;54:221-232. https://doi.org/10.1016/j.ssresearch.2015.08.001