Life-style risk factors for pancreatic cancer in louisiana: A case-control study

Roni T. Falk, Linda Williams Pickle, Elizabeth T. Fontham, Pelayo Correa, Joseph F. Fraumeni

Research output: Contribution to journalArticlepeer-review

260 Scopus citations

Abstract

A hospital-based, incident case-control study of pancreatic cancer was con ducted between 1979 and 1983 in parallel with similarly designed studies of lung and stomach cancers in high-risk areas of Louisiana. To evaluate life-style practices, including diet, the authors pooled controls from the three studies, and then excluded subjects with diet-altering chronic diseases. When the 363 cases were compared with the 1,234 identified controls, significantly elevated risks were found among persons with Cajun ancestry, especially in rural areas. Among current smokers, a significant twofold risk was associated with moderate (16-25 cigarettes per day) and heavy (≥26 cigarettes per day) consumption, while ex-smokers showed no consistent pattern of risk. After adjustment for potential confounding by smoking, diet, and demographic factors, the risk of pancreatic cancer was unrelated to use of alcoholic beverages or coffee. Pork products and rice were conspicuous as dietary risk factors, each showing a positive dose-response effect, whereas fruit consumption exerted a protective influence.

Original languageEnglish (US)
Pages (from-to)324-336
Number of pages13
JournalAmerican journal of epidemiology
Volume128
Issue number2
DOIs
StatePublished - Aug 1988

All Science Journal Classification (ASJC) codes

  • Epidemiology

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