Ligand-Free Copper-Catalyzed Negishi Coupling of Alkyl-, Aryl-, and Alkynylzinc Reagents with Heteroaryl Iodides

Surendra Thapa, Arjun Kafle, Santosh K. Gurung, Adam Montoya, Patrick Riedel, Ramesh Giri

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Reported herein is an unprecedented ligand-free copper-catalyzed cross-coupling of alkyl-, aryl-, and alkynylzinc reagents with heteroaryl iodides. The reaction proceeds at room temperature for the coupling of primary, secondary, and tertiary alkylzinc reagents with heteroaryl iodides without rearrangement. An elevated temperature (100 C) is required for aryl-heteroaryl and alkynyl-heteroaryl couplings.

Original languageEnglish (US)
Pages (from-to)8236-8240
Number of pages5
JournalAngewandte Chemie - International Edition
Volume54
Issue number28
DOIs
StatePublished - Jul 1 2015

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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