Limitations of 3-phenylpropionylglycine in early screening for medium-chain acyl-coenzyme A dehydrogenase deficiency

Ajay Bhala, Michael J. Bennett, Karin L. McGowan, Daniel Hale

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Screening for medium-chain acyl-coenzyme A dehydrogenase (MCAD) deficiency by urinary 3-phenylproplonylglycine may not be reliable in early infancy because young infants are not colonized with adult-type colonic flora. In this study we delineated the microbes that produce 3-phenylpropionic acid, the precursor of 3-phenylpropionylglycine. We found that the use of some antibiotics may alter gut flora, thereby confounding this method of screening for MCAD deficiency.

Original languageEnglish (US)
Pages (from-to)100-103
Number of pages4
JournalThe Journal of pediatrics
Volume122
Issue number1
DOIs
StatePublished - Jan 1 1993

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Anti-Bacterial Agents
3-phenylpropionylglycine
Medium chain acyl CoA dehydrogenase deficiency
3-phenylpropionic acid
Gastrointestinal Microbiome

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

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abstract = "Screening for medium-chain acyl-coenzyme A dehydrogenase (MCAD) deficiency by urinary 3-phenylproplonylglycine may not be reliable in early infancy because young infants are not colonized with adult-type colonic flora. In this study we delineated the microbes that produce 3-phenylpropionic acid, the precursor of 3-phenylpropionylglycine. We found that the use of some antibiotics may alter gut flora, thereby confounding this method of screening for MCAD deficiency.",
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Limitations of 3-phenylpropionylglycine in early screening for medium-chain acyl-coenzyme A dehydrogenase deficiency. / Bhala, Ajay; Bennett, Michael J.; McGowan, Karin L.; Hale, Daniel.

In: The Journal of pediatrics, Vol. 122, No. 1, 01.01.1993, p. 100-103.

Research output: Contribution to journalArticle

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AU - Bhala, Ajay

AU - Bennett, Michael J.

AU - McGowan, Karin L.

AU - Hale, Daniel

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AB - Screening for medium-chain acyl-coenzyme A dehydrogenase (MCAD) deficiency by urinary 3-phenylproplonylglycine may not be reliable in early infancy because young infants are not colonized with adult-type colonic flora. In this study we delineated the microbes that produce 3-phenylpropionic acid, the precursor of 3-phenylpropionylglycine. We found that the use of some antibiotics may alter gut flora, thereby confounding this method of screening for MCAD deficiency.

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