Linear end-systolic pressure-volume relationship during pulsatile left ventricular bypass represents native heart function

Osamu Kawaguchi, John S. Sapirstein, William B. Daily, Walter E. Pae, William S. Pierce

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

This study assessed whether the end-systolic pressure-volume relationship obtained without any interventions during pulsatile left ventricular bypass adequately represents native heart function. In 11 anesthetized Holstein calves, left ventricular pressure was measured with a micromanometer while left ventricular volume was simultaneously calculated from orthogonal left ventricular diameters measured with ultrasonic dimension transducers. End-systolic pressure and volume data were subjected to linear regression analysis to achieve an end-systolic pressure-volume relationship. Data from both caval occlusions and aortic occlusion were used for the control end-systolic pressure-volume relationship (median r = 0.941, slope = 7.4 ± 0.8 mm Hg per milliliter per 100 gm left ventricular weight; mean ± standard error of the mean). During left atrial-aortic bypass with a Pierce-Donachy pneumatic assist pump in the asynchronous mode, the end-systolic pressure-volume relationships were obtained without interventions to change ventricular loading conditions. During maximal ventricular unloading during full to empty pumping, termed 100%, the resulting narrow range of pressure and volume data did not yield highly linear end-systolic pressure-volume relationships (median r = 0.669, slope = 4.9 ± 0.9 mm Hg per milliliter per 100 gm left ventricular weight). However, at reduced rates off pumping, the end-systolic pressure-volume relationships were considerably linear (80%, median r = 0.819; 60%, median r = 0.868; 40%, median r = 0.899). Slopes did not significantly differ from control values (80%, 6.9 ± 1.1; 60%, 8.2 ± 1.1; 40%, 7.8 ± 1.1). The end-systolic pressure-volume relationship obtained without exogenous load changes during asynchronous, pulsatile left ventricular bypass represents native left ventricular systolic function. (J T HORAC C ARDIOVASC S URG 1995;109:780-6).

Original languageEnglish (US)
Pages (from-to)780-786
Number of pages7
JournalThe Journal of thoracic and cardiovascular surgery
Volume109
Issue number4
DOIs
StatePublished - Apr 1995

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Blood Pressure
Weights and Measures
Venae Cavae
Ventricular Pressure
Transducers
Left Ventricular Function
Ultrasonics
Linear Models
Regression Analysis
Pressure

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Kawaguchi, Osamu ; Sapirstein, John S. ; Daily, William B. ; Pae, Walter E. ; Pierce, William S. / Linear end-systolic pressure-volume relationship during pulsatile left ventricular bypass represents native heart function. In: The Journal of thoracic and cardiovascular surgery. 1995 ; Vol. 109, No. 4. pp. 780-786.
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abstract = "This study assessed whether the end-systolic pressure-volume relationship obtained without any interventions during pulsatile left ventricular bypass adequately represents native heart function. In 11 anesthetized Holstein calves, left ventricular pressure was measured with a micromanometer while left ventricular volume was simultaneously calculated from orthogonal left ventricular diameters measured with ultrasonic dimension transducers. End-systolic pressure and volume data were subjected to linear regression analysis to achieve an end-systolic pressure-volume relationship. Data from both caval occlusions and aortic occlusion were used for the control end-systolic pressure-volume relationship (median r = 0.941, slope = 7.4 ± 0.8 mm Hg per milliliter per 100 gm left ventricular weight; mean ± standard error of the mean). During left atrial-aortic bypass with a Pierce-Donachy pneumatic assist pump in the asynchronous mode, the end-systolic pressure-volume relationships were obtained without interventions to change ventricular loading conditions. During maximal ventricular unloading during full to empty pumping, termed 100{\%}, the resulting narrow range of pressure and volume data did not yield highly linear end-systolic pressure-volume relationships (median r = 0.669, slope = 4.9 ± 0.9 mm Hg per milliliter per 100 gm left ventricular weight). However, at reduced rates off pumping, the end-systolic pressure-volume relationships were considerably linear (80{\%}, median r = 0.819; 60{\%}, median r = 0.868; 40{\%}, median r = 0.899). Slopes did not significantly differ from control values (80{\%}, 6.9 ± 1.1; 60{\%}, 8.2 ± 1.1; 40{\%}, 7.8 ± 1.1). The end-systolic pressure-volume relationship obtained without exogenous load changes during asynchronous, pulsatile left ventricular bypass represents native left ventricular systolic function. (J T HORAC C ARDIOVASC S URG 1995;109:780-6).",
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Linear end-systolic pressure-volume relationship during pulsatile left ventricular bypass represents native heart function. / Kawaguchi, Osamu; Sapirstein, John S.; Daily, William B.; Pae, Walter E.; Pierce, William S.

In: The Journal of thoracic and cardiovascular surgery, Vol. 109, No. 4, 04.1995, p. 780-786.

Research output: Contribution to journalArticle

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AU - Sapirstein, John S.

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N2 - This study assessed whether the end-systolic pressure-volume relationship obtained without any interventions during pulsatile left ventricular bypass adequately represents native heart function. In 11 anesthetized Holstein calves, left ventricular pressure was measured with a micromanometer while left ventricular volume was simultaneously calculated from orthogonal left ventricular diameters measured with ultrasonic dimension transducers. End-systolic pressure and volume data were subjected to linear regression analysis to achieve an end-systolic pressure-volume relationship. Data from both caval occlusions and aortic occlusion were used for the control end-systolic pressure-volume relationship (median r = 0.941, slope = 7.4 ± 0.8 mm Hg per milliliter per 100 gm left ventricular weight; mean ± standard error of the mean). During left atrial-aortic bypass with a Pierce-Donachy pneumatic assist pump in the asynchronous mode, the end-systolic pressure-volume relationships were obtained without interventions to change ventricular loading conditions. During maximal ventricular unloading during full to empty pumping, termed 100%, the resulting narrow range of pressure and volume data did not yield highly linear end-systolic pressure-volume relationships (median r = 0.669, slope = 4.9 ± 0.9 mm Hg per milliliter per 100 gm left ventricular weight). However, at reduced rates off pumping, the end-systolic pressure-volume relationships were considerably linear (80%, median r = 0.819; 60%, median r = 0.868; 40%, median r = 0.899). Slopes did not significantly differ from control values (80%, 6.9 ± 1.1; 60%, 8.2 ± 1.1; 40%, 7.8 ± 1.1). The end-systolic pressure-volume relationship obtained without exogenous load changes during asynchronous, pulsatile left ventricular bypass represents native left ventricular systolic function. (J T HORAC C ARDIOVASC S URG 1995;109:780-6).

AB - This study assessed whether the end-systolic pressure-volume relationship obtained without any interventions during pulsatile left ventricular bypass adequately represents native heart function. In 11 anesthetized Holstein calves, left ventricular pressure was measured with a micromanometer while left ventricular volume was simultaneously calculated from orthogonal left ventricular diameters measured with ultrasonic dimension transducers. End-systolic pressure and volume data were subjected to linear regression analysis to achieve an end-systolic pressure-volume relationship. Data from both caval occlusions and aortic occlusion were used for the control end-systolic pressure-volume relationship (median r = 0.941, slope = 7.4 ± 0.8 mm Hg per milliliter per 100 gm left ventricular weight; mean ± standard error of the mean). During left atrial-aortic bypass with a Pierce-Donachy pneumatic assist pump in the asynchronous mode, the end-systolic pressure-volume relationships were obtained without interventions to change ventricular loading conditions. During maximal ventricular unloading during full to empty pumping, termed 100%, the resulting narrow range of pressure and volume data did not yield highly linear end-systolic pressure-volume relationships (median r = 0.669, slope = 4.9 ± 0.9 mm Hg per milliliter per 100 gm left ventricular weight). However, at reduced rates off pumping, the end-systolic pressure-volume relationships were considerably linear (80%, median r = 0.819; 60%, median r = 0.868; 40%, median r = 0.899). Slopes did not significantly differ from control values (80%, 6.9 ± 1.1; 60%, 8.2 ± 1.1; 40%, 7.8 ± 1.1). The end-systolic pressure-volume relationship obtained without exogenous load changes during asynchronous, pulsatile left ventricular bypass represents native left ventricular systolic function. (J T HORAC C ARDIOVASC S URG 1995;109:780-6).

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