Linkage map of mouse chromosome 17

Localization of 27 new DNA markers

Vladimir Vincek, Hiroshi Kawaguchi, Kazuya Mizuno, Zofia Zaleska-Rutczynska, Masanori Kasahara, Jiří Forejt, Felipe Figueroa, Jan Klein

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Chromosome 17 of the laboratory variant of the house mouse (Mus musculus L.), MMU17, has been studied extensively, largely because of its involvement in the control of immune response and embryonic as well as male germ cell differentiation. A detailed linkage map of this chromosome is therefore a highly desired goal. As the first step toward achieving this goal, we have isolated, using a LINE 1 repetitive sequence as a probe, 52 anonymous DNA clones from MMU17. Twenty-seven repetitive sequence-free probes isolated from these clones displayed restriction fragment length variation among common inbred strains and could be mapped with the help of recombinant inbred strains, congenic strains, F2 segregants, or intra-t recombinants. Together with markers identified previously, the new markers can be used to construct a map of MMU17 that contains 125 DNA loci. The markers are distributed over a length of approximately 71 cM, which probably represents the entire length of MMU17. Most of the markers reside in the proximal portion of the chromosome, which contains the t and H-2 complexes; this chromosomal region is now fairly well mapped. The distal region of MMU17, on the other hand, is populated by only a few, rather imprecisely mapped markers. Molecular maps are available for most of the H-2 complex and for parts of the t complex.

Original languageEnglish (US)
Pages (from-to)773-786
Number of pages14
JournalGenomics
Volume5
Issue number4
DOIs
StatePublished - Jan 1 1989

Fingerprint

Chromosomes, Human, Pair 17
Nucleic Acid Repetitive Sequences
Genetic Markers
Clone Cells
Chromosomes
DNA
Germ Cells
Cell Differentiation

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Vincek, V., Kawaguchi, H., Mizuno, K., Zaleska-Rutczynska, Z., Kasahara, M., Forejt, J., ... Klein, J. (1989). Linkage map of mouse chromosome 17: Localization of 27 new DNA markers. Genomics, 5(4), 773-786. https://doi.org/10.1016/0888-7543(89)90119-5
Vincek, Vladimir ; Kawaguchi, Hiroshi ; Mizuno, Kazuya ; Zaleska-Rutczynska, Zofia ; Kasahara, Masanori ; Forejt, Jiří ; Figueroa, Felipe ; Klein, Jan. / Linkage map of mouse chromosome 17 : Localization of 27 new DNA markers. In: Genomics. 1989 ; Vol. 5, No. 4. pp. 773-786.
@article{2346042bb4814f24a65a9163804ca4f5,
title = "Linkage map of mouse chromosome 17: Localization of 27 new DNA markers",
abstract = "Chromosome 17 of the laboratory variant of the house mouse (Mus musculus L.), MMU17, has been studied extensively, largely because of its involvement in the control of immune response and embryonic as well as male germ cell differentiation. A detailed linkage map of this chromosome is therefore a highly desired goal. As the first step toward achieving this goal, we have isolated, using a LINE 1 repetitive sequence as a probe, 52 anonymous DNA clones from MMU17. Twenty-seven repetitive sequence-free probes isolated from these clones displayed restriction fragment length variation among common inbred strains and could be mapped with the help of recombinant inbred strains, congenic strains, F2 segregants, or intra-t recombinants. Together with markers identified previously, the new markers can be used to construct a map of MMU17 that contains 125 DNA loci. The markers are distributed over a length of approximately 71 cM, which probably represents the entire length of MMU17. Most of the markers reside in the proximal portion of the chromosome, which contains the t and H-2 complexes; this chromosomal region is now fairly well mapped. The distal region of MMU17, on the other hand, is populated by only a few, rather imprecisely mapped markers. Molecular maps are available for most of the H-2 complex and for parts of the t complex.",
author = "Vladimir Vincek and Hiroshi Kawaguchi and Kazuya Mizuno and Zofia Zaleska-Rutczynska and Masanori Kasahara and Jiř{\'i} Forejt and Felipe Figueroa and Jan Klein",
year = "1989",
month = "1",
day = "1",
doi = "10.1016/0888-7543(89)90119-5",
language = "English (US)",
volume = "5",
pages = "773--786",
journal = "Genomics",
issn = "0888-7543",
publisher = "Academic Press Inc.",
number = "4",

}

Vincek, V, Kawaguchi, H, Mizuno, K, Zaleska-Rutczynska, Z, Kasahara, M, Forejt, J, Figueroa, F & Klein, J 1989, 'Linkage map of mouse chromosome 17: Localization of 27 new DNA markers', Genomics, vol. 5, no. 4, pp. 773-786. https://doi.org/10.1016/0888-7543(89)90119-5

Linkage map of mouse chromosome 17 : Localization of 27 new DNA markers. / Vincek, Vladimir; Kawaguchi, Hiroshi; Mizuno, Kazuya; Zaleska-Rutczynska, Zofia; Kasahara, Masanori; Forejt, Jiří; Figueroa, Felipe; Klein, Jan.

In: Genomics, Vol. 5, No. 4, 01.01.1989, p. 773-786.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Linkage map of mouse chromosome 17

T2 - Localization of 27 new DNA markers

AU - Vincek, Vladimir

AU - Kawaguchi, Hiroshi

AU - Mizuno, Kazuya

AU - Zaleska-Rutczynska, Zofia

AU - Kasahara, Masanori

AU - Forejt, Jiří

AU - Figueroa, Felipe

AU - Klein, Jan

PY - 1989/1/1

Y1 - 1989/1/1

N2 - Chromosome 17 of the laboratory variant of the house mouse (Mus musculus L.), MMU17, has been studied extensively, largely because of its involvement in the control of immune response and embryonic as well as male germ cell differentiation. A detailed linkage map of this chromosome is therefore a highly desired goal. As the first step toward achieving this goal, we have isolated, using a LINE 1 repetitive sequence as a probe, 52 anonymous DNA clones from MMU17. Twenty-seven repetitive sequence-free probes isolated from these clones displayed restriction fragment length variation among common inbred strains and could be mapped with the help of recombinant inbred strains, congenic strains, F2 segregants, or intra-t recombinants. Together with markers identified previously, the new markers can be used to construct a map of MMU17 that contains 125 DNA loci. The markers are distributed over a length of approximately 71 cM, which probably represents the entire length of MMU17. Most of the markers reside in the proximal portion of the chromosome, which contains the t and H-2 complexes; this chromosomal region is now fairly well mapped. The distal region of MMU17, on the other hand, is populated by only a few, rather imprecisely mapped markers. Molecular maps are available for most of the H-2 complex and for parts of the t complex.

AB - Chromosome 17 of the laboratory variant of the house mouse (Mus musculus L.), MMU17, has been studied extensively, largely because of its involvement in the control of immune response and embryonic as well as male germ cell differentiation. A detailed linkage map of this chromosome is therefore a highly desired goal. As the first step toward achieving this goal, we have isolated, using a LINE 1 repetitive sequence as a probe, 52 anonymous DNA clones from MMU17. Twenty-seven repetitive sequence-free probes isolated from these clones displayed restriction fragment length variation among common inbred strains and could be mapped with the help of recombinant inbred strains, congenic strains, F2 segregants, or intra-t recombinants. Together with markers identified previously, the new markers can be used to construct a map of MMU17 that contains 125 DNA loci. The markers are distributed over a length of approximately 71 cM, which probably represents the entire length of MMU17. Most of the markers reside in the proximal portion of the chromosome, which contains the t and H-2 complexes; this chromosomal region is now fairly well mapped. The distal region of MMU17, on the other hand, is populated by only a few, rather imprecisely mapped markers. Molecular maps are available for most of the H-2 complex and for parts of the t complex.

UR - http://www.scopus.com/inward/record.url?scp=0024759520&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024759520&partnerID=8YFLogxK

U2 - 10.1016/0888-7543(89)90119-5

DO - 10.1016/0888-7543(89)90119-5

M3 - Article

VL - 5

SP - 773

EP - 786

JO - Genomics

JF - Genomics

SN - 0888-7543

IS - 4

ER -

Vincek V, Kawaguchi H, Mizuno K, Zaleska-Rutczynska Z, Kasahara M, Forejt J et al. Linkage map of mouse chromosome 17: Localization of 27 new DNA markers. Genomics. 1989 Jan 1;5(4):773-786. https://doi.org/10.1016/0888-7543(89)90119-5