Linkage mapping of sex-specific differences

Rongling Wu, Chang Xing Ma, S. S. Wu, Zhao Bang Zeng

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Most current linkage analyses assume identical fractions of meiotic recombination between homologous marker loci of the two sexes. This assumption is not realistic, because considerable sex-related differences have been observed in recombination fraction. In this paper, a general EM-based algorithm is presented to estimate sex-specific recombination fractions for a mixed set of molecular markers segregating differently in a full-sib family derived from two heterozygous parents. The asymptotic variances of the estimates of linkage specifically for each of the parents are evaluated using a numerical analysis based on information functions. This approach will have important implications for precise gene mapping based on sex-specific linkage maps.

Original languageEnglish (US)
Pages (from-to)85-96
Number of pages12
JournalGenetical research
Volume79
Issue number1
DOIs
StatePublished - Apr 9 2002

All Science Journal Classification (ASJC) codes

  • Genetics

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