Linking the Gut Microbiota to Bone Health in Anorexia Nervosa

Nicole C. Aurigemma, Kristen J. Koltun, Hannah VanEvery, Connie Jo Rogers, Mary Jane De Souza

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Purpose of Review: The purpose of this review is to examine the anorexia nervosa-microbiota-bone relationship, offering a compilation of the relevant human and animal studies that may contribute to a more comprehensive understanding of potential mechanisms involved. Recent Findings: Recent studies have implicated fermentation by-products of the gut microbiota in bone metabolism. Summary: Compromised bone health often accompanies anorexia nervosa due to energy deficiency and hypoestrogenism. The gut microbiome has been implicated as a link between these conditions and impaired bone growth phenotypes. Current research supports decrements in Firmicutes and short-chain fatty acids with increases in Methanobrevibacter smithii and Proteobacteria in anorexia nervosa. A potential mechanism for microbiome-regulated bone growth is through modulation of insulin-like growth factor-1. Future research should aim to examine short-chain fatty acids, probiotics, and prebiotics as alternative therapies to treat low bone density in anorexia nervosa.

Original languageEnglish (US)
Pages (from-to)65-75
Number of pages11
JournalCurrent Osteoporosis Reports
Volume16
Issue number1
DOIs
StatePublished - Feb 1 2018

Fingerprint

Anorexia Nervosa
Volatile Fatty Acids
Microbiota
Bone Development
Health
Bone and Bones
Methanobrevibacter
Proteobacteria
Prebiotics
Probiotics
Somatomedins
Complementary Therapies
Bone Density
Fermentation
Phenotype
Gastrointestinal Microbiome
Research

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism

Cite this

Aurigemma, Nicole C. ; Koltun, Kristen J. ; VanEvery, Hannah ; Rogers, Connie Jo ; De Souza, Mary Jane. / Linking the Gut Microbiota to Bone Health in Anorexia Nervosa. In: Current Osteoporosis Reports. 2018 ; Vol. 16, No. 1. pp. 65-75.
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Linking the Gut Microbiota to Bone Health in Anorexia Nervosa. / Aurigemma, Nicole C.; Koltun, Kristen J.; VanEvery, Hannah; Rogers, Connie Jo; De Souza, Mary Jane.

In: Current Osteoporosis Reports, Vol. 16, No. 1, 01.02.2018, p. 65-75.

Research output: Contribution to journalReview article

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