Lipocalin 2: An Emerging Player in Iron Homeostasis and Inflammation

Xia Xiao, Beng San Yeoh, Matam Vijay-Kumar

Research output: Contribution to journalReview article

29 Citations (Scopus)

Abstract

Lipocalin 2 (Lcn2), an innate immune protein, has emerged as a critical iron regulatory protein during physiological and inflammatory conditions. As a bacteriostatic factor, Lcn2 obstructs the siderophore iron-acquiring strategy of bacteria and thus inhibits bacterial growth. As part of host nutritional immunity, Lcn2 facilitates systemic, cellular, and mucosal hypoferremia during inflammation, in addition to stabilizing the siderophore-bound labile iron pool. In this review, we summarize recent advances in understanding the interaction between Lcn2 and iron, and its effects in various inflammatory diseases. Lcn2 exerts mostly a protective role in infectious and inflammatory bowel diseases, whereas both beneficial and detrimental functions have been documented in neurodegenerative diseases, metabolic syndrome, renal disorders, skin disorders, and cancer. Further animal and clinical studies are necessary to unveil the multifaceted roles of Lcn2 in iron dysregulation during inflammation and to explore its therapeutic potential for treating inflammatory diseases.

Original languageEnglish (US)
Pages (from-to)103-130
Number of pages28
JournalAnnual Review of Nutrition
Volume37
DOIs
StatePublished - Aug 21 2017

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Homeostasis
Iron
Inflammation
Siderophores
Iron-Regulatory Proteins
Skin Neoplasms
Inflammatory Bowel Diseases
Neurodegenerative Diseases
Lipocalin-2
Immunity
Bacteria
Kidney
Growth
Proteins
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Xiao, Xia ; Yeoh, Beng San ; Vijay-Kumar, Matam. / Lipocalin 2 : An Emerging Player in Iron Homeostasis and Inflammation. In: Annual Review of Nutrition. 2017 ; Vol. 37. pp. 103-130.
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Lipocalin 2 : An Emerging Player in Iron Homeostasis and Inflammation. / Xiao, Xia; Yeoh, Beng San; Vijay-Kumar, Matam.

In: Annual Review of Nutrition, Vol. 37, 21.08.2017, p. 103-130.

Research output: Contribution to journalReview article

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AU - Xiao, Xia

AU - Yeoh, Beng San

AU - Vijay-Kumar, Matam

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Y1 - 2017/8/21

N2 - Lipocalin 2 (Lcn2), an innate immune protein, has emerged as a critical iron regulatory protein during physiological and inflammatory conditions. As a bacteriostatic factor, Lcn2 obstructs the siderophore iron-acquiring strategy of bacteria and thus inhibits bacterial growth. As part of host nutritional immunity, Lcn2 facilitates systemic, cellular, and mucosal hypoferremia during inflammation, in addition to stabilizing the siderophore-bound labile iron pool. In this review, we summarize recent advances in understanding the interaction between Lcn2 and iron, and its effects in various inflammatory diseases. Lcn2 exerts mostly a protective role in infectious and inflammatory bowel diseases, whereas both beneficial and detrimental functions have been documented in neurodegenerative diseases, metabolic syndrome, renal disorders, skin disorders, and cancer. Further animal and clinical studies are necessary to unveil the multifaceted roles of Lcn2 in iron dysregulation during inflammation and to explore its therapeutic potential for treating inflammatory diseases.

AB - Lipocalin 2 (Lcn2), an innate immune protein, has emerged as a critical iron regulatory protein during physiological and inflammatory conditions. As a bacteriostatic factor, Lcn2 obstructs the siderophore iron-acquiring strategy of bacteria and thus inhibits bacterial growth. As part of host nutritional immunity, Lcn2 facilitates systemic, cellular, and mucosal hypoferremia during inflammation, in addition to stabilizing the siderophore-bound labile iron pool. In this review, we summarize recent advances in understanding the interaction between Lcn2 and iron, and its effects in various inflammatory diseases. Lcn2 exerts mostly a protective role in infectious and inflammatory bowel diseases, whereas both beneficial and detrimental functions have been documented in neurodegenerative diseases, metabolic syndrome, renal disorders, skin disorders, and cancer. Further animal and clinical studies are necessary to unveil the multifaceted roles of Lcn2 in iron dysregulation during inflammation and to explore its therapeutic potential for treating inflammatory diseases.

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