Liquid biopsy in central nervous system metastases: A RANO review and proposals for clinical applications

Adrienne Boire, Dieta Brandsma, Priscilla K. Brastianos, Emilie Le Rhun, Manmeet Ahluwalia, Larry Junck, Michael Glantz, Morris D. Groves, Eudocia Q. Lee, Nancy Lin, Jeffrey Raizer, Roberta Rudà, Michael Weller, Martin J. Van Den Bent, Michael A. Vogelbaum, Susan Chang, Patrick Y. Wen, Riccardo Soffietti

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Liquid biopsies collect and analyze tumor components in body fluids, and there is an increasing interest in the investigation of liquid biopsies as a surrogate for tumor tissue in the management of both primary and secondary brain tumors. Herein we critically review available literature on spinal fluid and plasma circulating tumor cells (CTCs) and cell-free tumor (ctDNA) for diagnosis and monitoring of leptomeningeal and parenchymal brain metastases. We discuss technical issues and propose several potential applications of liquid biopsies in different clinical settings (ie, for initial diagnosis, for assessment during treatment, and for guidance of treatment decisions). Last, ongoing clinical studies on CNS metastases that include liquid biopsies are summarized, and recommendations for future clinical studies are provided.

Original languageEnglish (US)
Pages (from-to)571-583
Number of pages13
JournalNeuro-oncology
Volume21
Issue number5
DOIs
StatePublished - May 1 2019

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Central Nervous System
Neoplasm Metastasis
Biopsy
Circulating Neoplastic Cells
Neoplasms
Body Fluids
Plasma Cells
Brain Neoplasms
Brain
Clinical Studies

All Science Journal Classification (ASJC) codes

  • Oncology
  • Clinical Neurology
  • Cancer Research

Cite this

Boire, A., Brandsma, D., Brastianos, P. K., Le Rhun, E., Ahluwalia, M., Junck, L., ... Soffietti, R. (2019). Liquid biopsy in central nervous system metastases: A RANO review and proposals for clinical applications. Neuro-oncology, 21(5), 571-583. https://doi.org/10.1093/neuonc/noz012
Boire, Adrienne ; Brandsma, Dieta ; Brastianos, Priscilla K. ; Le Rhun, Emilie ; Ahluwalia, Manmeet ; Junck, Larry ; Glantz, Michael ; Groves, Morris D. ; Lee, Eudocia Q. ; Lin, Nancy ; Raizer, Jeffrey ; Rudà, Roberta ; Weller, Michael ; Van Den Bent, Martin J. ; Vogelbaum, Michael A. ; Chang, Susan ; Wen, Patrick Y. ; Soffietti, Riccardo. / Liquid biopsy in central nervous system metastases : A RANO review and proposals for clinical applications. In: Neuro-oncology. 2019 ; Vol. 21, No. 5. pp. 571-583.
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Boire, A, Brandsma, D, Brastianos, PK, Le Rhun, E, Ahluwalia, M, Junck, L, Glantz, M, Groves, MD, Lee, EQ, Lin, N, Raizer, J, Rudà, R, Weller, M, Van Den Bent, MJ, Vogelbaum, MA, Chang, S, Wen, PY & Soffietti, R 2019, 'Liquid biopsy in central nervous system metastases: A RANO review and proposals for clinical applications', Neuro-oncology, vol. 21, no. 5, pp. 571-583. https://doi.org/10.1093/neuonc/noz012

Liquid biopsy in central nervous system metastases : A RANO review and proposals for clinical applications. / Boire, Adrienne; Brandsma, Dieta; Brastianos, Priscilla K.; Le Rhun, Emilie; Ahluwalia, Manmeet; Junck, Larry; Glantz, Michael; Groves, Morris D.; Lee, Eudocia Q.; Lin, Nancy; Raizer, Jeffrey; Rudà, Roberta; Weller, Michael; Van Den Bent, Martin J.; Vogelbaum, Michael A.; Chang, Susan; Wen, Patrick Y.; Soffietti, Riccardo.

In: Neuro-oncology, Vol. 21, No. 5, 01.05.2019, p. 571-583.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Liquid biopsy in central nervous system metastases

T2 - A RANO review and proposals for clinical applications

AU - Boire, Adrienne

AU - Brandsma, Dieta

AU - Brastianos, Priscilla K.

AU - Le Rhun, Emilie

AU - Ahluwalia, Manmeet

AU - Junck, Larry

AU - Glantz, Michael

AU - Groves, Morris D.

AU - Lee, Eudocia Q.

AU - Lin, Nancy

AU - Raizer, Jeffrey

AU - Rudà, Roberta

AU - Weller, Michael

AU - Van Den Bent, Martin J.

AU - Vogelbaum, Michael A.

AU - Chang, Susan

AU - Wen, Patrick Y.

AU - Soffietti, Riccardo

PY - 2019/5/1

Y1 - 2019/5/1

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AB - Liquid biopsies collect and analyze tumor components in body fluids, and there is an increasing interest in the investigation of liquid biopsies as a surrogate for tumor tissue in the management of both primary and secondary brain tumors. Herein we critically review available literature on spinal fluid and plasma circulating tumor cells (CTCs) and cell-free tumor (ctDNA) for diagnosis and monitoring of leptomeningeal and parenchymal brain metastases. We discuss technical issues and propose several potential applications of liquid biopsies in different clinical settings (ie, for initial diagnosis, for assessment during treatment, and for guidance of treatment decisions). Last, ongoing clinical studies on CNS metastases that include liquid biopsies are summarized, and recommendations for future clinical studies are provided.

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Boire A, Brandsma D, Brastianos PK, Le Rhun E, Ahluwalia M, Junck L et al. Liquid biopsy in central nervous system metastases: A RANO review and proposals for clinical applications. Neuro-oncology. 2019 May 1;21(5):571-583. https://doi.org/10.1093/neuonc/noz012