Liquid chromatography-atmospheric pressure photoionization tandem mass spectrometry for analysis of 36 halogenated flame retardants in fish

Simon Ningsun Zhou, Eric J. Reiner, Chris Marvin, Terry Kolic, Nicole Riddell, Paul Helm, Franklin Lewis Dorman, Jr., Michelle Misselwitz, Ian D. Brindle

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

A comprehensive, sensitive and high-throughput liquid chromatography-atmospheric pressure photoionization tandem mass spectrometry (LC-APPI-MS/MS) method has been developed for analysis of 36 halogenated flame retardants (HFRs). Under the optimized LC conditions, all of the HFRs eluted from the LC column within 14 min, while maintaining good chromatographic separation for the isomers. Introduction of the pre-heated dopant to the APPI source decreased the background noise fivefold, which enhanced sensitivity. An empirical equation was proposed to describe the relation between the ion intensity and dopant flow. The excellent on-column instrument detection limits averaged 4.7 pg, which was similar to the sensitivity offered by gas chromatography-high-resolution mass spectrometry (GC-HRMS). This method was used to analyze a series of fish samples. Good agreement was found between the results for PBDEs from LC-APPI-MS/MS and GC-HRMS.

Original languageEnglish (US)
Pages (from-to)633-641
Number of pages9
JournalJournal of Chromatography A
Volume1217
Issue number5
DOIs
StatePublished - Jan 29 2010

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Flame Retardants
Photoionization
Atmospheric Pressure
Liquid chromatography
Tandem Mass Spectrometry
Liquid Chromatography
Gas Chromatography
Fish
Atmospheric pressure
Mass spectrometry
Mass Spectrometry
Fishes
Halogenated Diphenyl Ethers
Gas chromatography
Doping (additives)
Noise
Limit of Detection
Ions
Isomers
Throughput

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

Cite this

Zhou, Simon Ningsun ; Reiner, Eric J. ; Marvin, Chris ; Kolic, Terry ; Riddell, Nicole ; Helm, Paul ; Dorman, Jr., Franklin Lewis ; Misselwitz, Michelle ; Brindle, Ian D. / Liquid chromatography-atmospheric pressure photoionization tandem mass spectrometry for analysis of 36 halogenated flame retardants in fish. In: Journal of Chromatography A. 2010 ; Vol. 1217, No. 5. pp. 633-641.
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abstract = "A comprehensive, sensitive and high-throughput liquid chromatography-atmospheric pressure photoionization tandem mass spectrometry (LC-APPI-MS/MS) method has been developed for analysis of 36 halogenated flame retardants (HFRs). Under the optimized LC conditions, all of the HFRs eluted from the LC column within 14 min, while maintaining good chromatographic separation for the isomers. Introduction of the pre-heated dopant to the APPI source decreased the background noise fivefold, which enhanced sensitivity. An empirical equation was proposed to describe the relation between the ion intensity and dopant flow. The excellent on-column instrument detection limits averaged 4.7 pg, which was similar to the sensitivity offered by gas chromatography-high-resolution mass spectrometry (GC-HRMS). This method was used to analyze a series of fish samples. Good agreement was found between the results for PBDEs from LC-APPI-MS/MS and GC-HRMS.",
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Zhou, SN, Reiner, EJ, Marvin, C, Kolic, T, Riddell, N, Helm, P, Dorman, Jr., FL, Misselwitz, M & Brindle, ID 2010, 'Liquid chromatography-atmospheric pressure photoionization tandem mass spectrometry for analysis of 36 halogenated flame retardants in fish', Journal of Chromatography A, vol. 1217, no. 5, pp. 633-641. https://doi.org/10.1016/j.chroma.2009.11.096

Liquid chromatography-atmospheric pressure photoionization tandem mass spectrometry for analysis of 36 halogenated flame retardants in fish. / Zhou, Simon Ningsun; Reiner, Eric J.; Marvin, Chris; Kolic, Terry; Riddell, Nicole; Helm, Paul; Dorman, Jr., Franklin Lewis; Misselwitz, Michelle; Brindle, Ian D.

In: Journal of Chromatography A, Vol. 1217, No. 5, 29.01.2010, p. 633-641.

Research output: Contribution to journalArticle

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T1 - Liquid chromatography-atmospheric pressure photoionization tandem mass spectrometry for analysis of 36 halogenated flame retardants in fish

AU - Zhou, Simon Ningsun

AU - Reiner, Eric J.

AU - Marvin, Chris

AU - Kolic, Terry

AU - Riddell, Nicole

AU - Helm, Paul

AU - Dorman, Jr., Franklin Lewis

AU - Misselwitz, Michelle

AU - Brindle, Ian D.

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