Litomosoides sigmodontis: Vaccine-induced immune responses against Wolbachia surface protein can enhance the survival of filarial nematodes during primary infection

Tracey J. Lamb, Anjanette Harris, Laetitia Le Goff, Andrew Fraser Read, Judith E. Allen

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Wolbachia are bacteria present within the tissues of most filarial nematodes. Filarial nematode survival is known to be affected by immune responses generated during filarial nematode infection and immune responses to Wolbachia can be found in different species harbouring filarial nematode infections, including humans. Using the rodent filarial model Litomosoides sigmodontis, we show that pre-exposure to wolbachia surface protein in a Th1 context (but not in a Th2-context) enhances worm survival on subsequent challenge. This study suggests that despite abundant evidence that pro-inflammatory reactions to the endosymbiont have detrimental effects on the both the nematode and mammalian host, they may under some circumstances be beneficial to the nematode.

Original languageEnglish (US)
Pages (from-to)285-289
Number of pages5
JournalExperimental Parasitology
Volume118
Issue number2
DOIs
StatePublished - Feb 1 2008

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Immunology

Fingerprint Dive into the research topics of 'Litomosoides sigmodontis: Vaccine-induced immune responses against Wolbachia surface protein can enhance the survival of filarial nematodes during primary infection'. Together they form a unique fingerprint.

  • Cite this