Liver as a source of transformed cell growth factor

Elizabeth Witkoski, Mary F. Schuler, Richard C. Feldhoff, Samson I. Jacob, Leonard S. Jefferson, Allan Lipton

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Abstract

Isolated rat hepatocytes release an acidic glycoprotein(s) that can selectively promote the growth of transformed cells. This factor has a molecular weight of 60 000-70 000 D. Liver microsomal and cytosol fractions contain two species of stimulatory activity-44 000 and 3 500 D. Mitochondrial and nuclear fractions contain only the lower molecular weight factor.

Original languageEnglish (US)
Pages (from-to)261-267
Number of pages7
JournalExperimental Cell Research
Volume124
Issue number2
DOIs
Publication statusPublished - Dec 1979

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All Science Journal Classification (ASJC) codes

  • Cell Biology

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