Abstract
Local cerebral blood flow was measured in anaesthetized beagle dogs by the hydrogen clearance method. Dopamine was administered as a continuous intravenous infusion of varying doses. The changes in local cerebral blood flow induced by dopamine were similar at the different locations; i.e., the caudate nucleus, thalamus, frontal and parietal cortex. Blood flow responded to dopamine in the following ways: low dose (< 2 μg/kg/min): blood flow decreased or remained unchanged; moderate doses (2-6 μg/kg/min): blood flow increased at all electrodes; high doses (7-20 μg/kg/min): blood flow decreased once again. The decrease in blood flow could be inhibited by the alpha-adrenergic receptor antagonist phentolamine or by the serotonin receptor antagonist methysergide. This indicates that the constrictor effect of dopamine on cerebral blood vessels is mediated via alpha-adrenergic receptors as well as via serotonin receptors. The increase in cerebral flow could be inhibited by the dopamine receptor antagonist haloperidol, indicating vascular dopamine receptors in the brain with a dilating effect. When the vasoconstrictor activity of dopamine is blocked, the single response to a dopamine infusion is a blood flow increase. This might be beneficial in the clinical situation of symptomatic vasospasm.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 181-188 |
| Number of pages | 8 |
| Journal | Surgical Neurology |
| Volume | 13 |
| Issue number | 3 |
| State | Published - May 9 1980 |
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All Science Journal Classification (ASJC) codes
- Surgery
- Clinical Neurology
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Local cerebral blood flow in the dog during intravenous infusion of dopamine. / von Essen, C.; Zervas, N. T.; Brown, D. R.; Koltun, W. A.; Pickren, K. S.
In: Surgical Neurology, Vol. 13, No. 3, 09.05.1980, p. 181-188.Research output: Contribution to journal › Article
TY - JOUR
T1 - Local cerebral blood flow in the dog during intravenous infusion of dopamine
AU - von Essen, C.
AU - Zervas, N. T.
AU - Brown, D. R.
AU - Koltun, W. A.
AU - Pickren, K. S.
PY - 1980/5/9
Y1 - 1980/5/9
N2 - Local cerebral blood flow was measured in anaesthetized beagle dogs by the hydrogen clearance method. Dopamine was administered as a continuous intravenous infusion of varying doses. The changes in local cerebral blood flow induced by dopamine were similar at the different locations; i.e., the caudate nucleus, thalamus, frontal and parietal cortex. Blood flow responded to dopamine in the following ways: low dose (< 2 μg/kg/min): blood flow decreased or remained unchanged; moderate doses (2-6 μg/kg/min): blood flow increased at all electrodes; high doses (7-20 μg/kg/min): blood flow decreased once again. The decrease in blood flow could be inhibited by the alpha-adrenergic receptor antagonist phentolamine or by the serotonin receptor antagonist methysergide. This indicates that the constrictor effect of dopamine on cerebral blood vessels is mediated via alpha-adrenergic receptors as well as via serotonin receptors. The increase in cerebral flow could be inhibited by the dopamine receptor antagonist haloperidol, indicating vascular dopamine receptors in the brain with a dilating effect. When the vasoconstrictor activity of dopamine is blocked, the single response to a dopamine infusion is a blood flow increase. This might be beneficial in the clinical situation of symptomatic vasospasm.
AB - Local cerebral blood flow was measured in anaesthetized beagle dogs by the hydrogen clearance method. Dopamine was administered as a continuous intravenous infusion of varying doses. The changes in local cerebral blood flow induced by dopamine were similar at the different locations; i.e., the caudate nucleus, thalamus, frontal and parietal cortex. Blood flow responded to dopamine in the following ways: low dose (< 2 μg/kg/min): blood flow decreased or remained unchanged; moderate doses (2-6 μg/kg/min): blood flow increased at all electrodes; high doses (7-20 μg/kg/min): blood flow decreased once again. The decrease in blood flow could be inhibited by the alpha-adrenergic receptor antagonist phentolamine or by the serotonin receptor antagonist methysergide. This indicates that the constrictor effect of dopamine on cerebral blood vessels is mediated via alpha-adrenergic receptors as well as via serotonin receptors. The increase in cerebral flow could be inhibited by the dopamine receptor antagonist haloperidol, indicating vascular dopamine receptors in the brain with a dilating effect. When the vasoconstrictor activity of dopamine is blocked, the single response to a dopamine infusion is a blood flow increase. This might be beneficial in the clinical situation of symptomatic vasospasm.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018833582&partnerID=8YFLogxK
M3 - Article
C2 - 7368065
AN - SCOPUS:0018833582
VL - 13
SP - 181
EP - 188
JO - World Neurosurgery
JF - World Neurosurgery
SN - 1878-8750
IS - 3
ER -